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PLoS One特刊：负面，阴性结果与无结果文章合集
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PLoS One杂志推出了一个特刊，名称为The Missing Pieces，专门刊发阴性结果，无结果或无法得出结论的研究论文。 PLoS One在业界一直存在争议，有褒有贬，但无论如何，经过短短数年成长，已成为期刊界重要的一分子之一。此次刊发特刊，PLoS的编辑们表示负结果对科学研究同样有价值同样重要，可以向科学家提供平衡的观点，可以节约宝贵的科研投入。 The Missing Pieces: A Collection of Negative, Null and Inconclusive Results 编辑对此做出了如下评价： The publication of negative, null and inconclusive results is important to provide scientists with balanced information and avoid the duplication of efforts testing similar hypotheses, which waste valuable time and research resources in the process. PLOS ONE considers all work that makes a contribution to the field, independent of impact. This includes negative findings which are valuable to the community in cases where the result is illuminating in the context of previous work. 具体链接：www.ploscollections.org/missingpieces 实际上，有关阴性结果文章是否有价值，一直存在争议。在此前还有一本专门刊发阴性结果的期刊问世：Journal of Negative Results in BioMedicine,不过据小编查询，目前未进入SCI收录。 那么阴性结果，负面结果或无结论结果，是否有价值呢？一般在研究过程中，大家都喜欢阳性结果，尤其是基础研究中，一些阴性结果，往往被冠以“此次实验操作欠佳”而抛弃，最终得出的都是阳性结果。从某种程度上，这种方式已影响到成果的转化。因为大量基础研究成果，到其它实验室并不能很好地重复，甚至不能重复。 不过，临床研究中，一般认为阴性结果可能比较阳性结果更重要。在四大医学期刊中，据有关机构统计，约有30%文章为阴性结果。这一点与基础研究有很大差别。 虽然，阴性结果一般被认为是不光彩的，但从科学意义上说，阴性结果同样重要，如果只汇报阳性结果，很容易造成发表偏倚，制造出各种假象。小编认为，临床研究中，对阴性结果的重视，使得临床研究可重复性很高；而基础研究阴性结果几乎无法发表，这也可能是造成大量基础研究结果难以重复的重要原因之一。 研究中如何正确呈现结果，显得至关重要。在最早iPS诱导时，实际上，出现iPS的概率相当低，大量尝试都是失败的，只有极少数能成功诱导出iPS，但最终产生了划时代的成果。而在普通的实验中，如果抛弃阴性结果，可能会带来重要信息的丢失，可能并不利于科学进步。PLoS One对阴性结果的发表，也许推动学界对阴性结果，无法得出结论的结果，给予更客观地评价。 当然，小编仔细审查这一期合集，并没有读者的担心，虽然都是发表阴性结果或负面结果，但文章质量并不比正刊的质量差。下面列举一些文章： Lack of an Antibacterial Response Defect in Drosophila Toll-9 Mutant Karine Narbonne-Reveau, Bernard Charroux, Julien Royet PLOS ONE: published 28 Feb 2011 | info:doi/10.1371/journal.pone.0017470 Abstract • Figures T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication Randi K. Berg, Stine H. Rahbek, Emil Kofod-Olsen, Christian K. Holm, Jesper Melchjorsen, David G. Jensen, Anne Louise Hansen, Louise B. Jørgensen, Lars Ostergaard, Martin Tolstrup, Carsten S. Larsen, Søren R. Paludan, Martin R. Jakobsen, Trine H. Mogensen PLOS ONE: published 03 Jan 2014 | info:doi/10.1371/journal.pone.0084513 Abstract • Figures Implicitly Priming the Social Brain: Failure to Find Neural Effects Katherine E. Powers, Todd F. Heatherton PLOS ONE: published 20 Feb 2013 | info:doi/10.1371/journal.pone.0056596 Abstract • Figures Impact of a Participatory Intervention with Women’s Groups on Psychological Distress among Mothers in Rural Bangladesh: Secondary Analysis of a Cluster-Randomised Controlled Trial Kelly Clarke, Kishwar Azad, Abdul Kuddus, Sanjit Shaha, Tasmin Nahar, Bedowra Haq Aumon, Mohammed Munir Hossen, James Beard, Anthony Costello, Tanja A. J. Houweling, Audrey Prost, Edward Fottrell PLOS ONE: published 16 Oct 2014 | info:doi/10.1371/journal.pone.0110697 Abstract • Figures A Capsaicin (8%) Patch in the Treatment of Severe Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled Trial Joakim M. Bischoff, Thomas K. Ringsted, Marian Petersen, Claudia Sommer, Nurcan üçeyler, Mads U. Werner PLOS ONE: published 07 Oct 2014 | info:doi/10.1371/journal.pone.0109144 Abstract • Figures Gameplay as a Source of Intrinsic Motivation in a Randomized Controlled Trial of Auditory Training for Tinnitus Derek J. Hoare, Nicolas Van Labeke, Abby McCormack, Magdalena Sereda, Sandra Smith, Hala Al Taher, Victoria L. Kowalkowski, Mike Sharples, Deborah A. Hall PLOS ONE: published 12 Sep 2014 | info:doi/10.1371/journal.pone.0107430 Abstract • Figures Keratinocytes Propagated in Serum-Free, Feeder-Free Culture Conditions Fail to Form Stratified Epidermis in a Reconstituted Skin Model Rebecca Lamb, Carrie A. Ambler PLOS ONE: published 11 Jan 2013 | info:doi/10.1371/journal.pone.0052494 Abstract • Figures Untrained Chimpanzees (Pan troglodytes schweinfurthii) Fail to Imitate Novel Actions Claudio Tennie, Josep Call, Michael Tomasello PLOS ONE: published 08 Aug 2012 | info:doi/10.1371/journal.pone.0041548 Abstract • Figures High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain Martin C. Herzig, Michael Bidinosti, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Andreas Weiss, Simone Danner, Nella Vidotto, Daniela Stauffer, Carmen Barske, Franziska Mayer, Peter Schmid, Giorgio Rovelli, P. Herman van der Putten, Derya R. Shimshek PLOS ONE: published 15 May 2012 | info:doi/10.1371/journal.pone.0036581 Abstract • Figures Curated MicroRNAs in Urine and Blood Fail to Validate as Predictive Biomarkers for High-Risk Prostate Cancer Nikhil Sapre, Matthew K. H. Hong, Geoff Macintyre, Heather Lewis, Adam Kowalczyk, Anthony J. Costello, Niall M. Corcoran, Christopher M. Hovens PLOS ONE: published 04 Apr 2014 | info:doi/10.1371/journal.pone.0091729 Abstract • Figures Lack of Evidence for mtDNA as a Biomarker of Innate Immune Activation in HIV Infection Adam S. Lauring, Tzong-Hae Lee, Jeffrey N. Martin, Peter W. Hunt, Steven G. Deeks, Michael Busch PLOS ONE: published 29 Nov 2012 | info:doi/10.1371/journal.pone.0050486 Abstract • Figures Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy Cholesterol Treatment Trialists' (CTT) Collaboration PLOS ONE: published 19 Jan 2012 | info:doi/10.1371/journal.pone.0029849 Abstract • Figures Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study Mady Hornig, Thomas Briese, Timothy Buie, Margaret L. Bauman, Gregory Lauwers, Ulrike Siemetzki, Kimberly Hummel, Paul A. Rota, William J. Bellini, John J. O'Leary, Orla Sheils, Errol Alden, Larry Pickering, W. Ian Lipkin PLOS ONE: published 04 Sep 2008 | info:doi/10.1371/journal.pone.0003140 Abstract • Figures The Influence of Partner-Specific Memory Associations on Picture Naming: A Failure to Replicate Horton (2007) Sarah Brown-Schmidt, William S. Horton PLOS ONE: published 03 Oct 2014 | info:doi/10.1371/journal.pone.0109035 Abstract • Figures Why Publishing Everything Is More Effective than Selective Publishing of Statistically Significant Results Marcel A. L. M. van Assen, Robbie C. M. van Aert, Michèle B. Nuijten, Jelte M. Wicherts PLOS ONE: published 17 Jan 2014 | info:doi/10.1371/journal.pone.0084896 Abstract • Figures Failing the Future: Three Unsuccessful Attempts to Replicate Bem's ‘Retroactive Facilitation of Recall’ Effect Stuart J. Ritchie, Richard Wiseman, Christopher C. French PLOS ONE: published 14 Mar 2012 | info:doi/10.1371/journal.pone.0033423 Abstract • Figures Priming of Social Distance? Failure to Replicate Effects on Social and Food Judgments Harold Pashler, Noriko Coburn, Christine R. Harris PLOS ONE: published 29 Aug 2012 | info:doi/10.1371/journal.pone.0042510 Abstract • Figures Two Failures to Replicate High-Performance-Goal Priming Effects Christine R. Harris, Noriko Coburn, Doug Rohrer, Harold Pashler PLOS ONE: published 16 Aug 2013 | info:doi/10.1371/journal.pone.0072467 Abstract • Figures Failure to Replicate Depletion of Self-ControlXiaomeng Xu, Kathryn E. Demos, Tricia M. Leahey, Chantelle N. Hart, Jennifer Trautvetter, Pamela Coward, Kathryn R. Middleton, Rena R. Wing PLOS ONE: published 21 Oct 2014 | info:doi/10.1371/journal.pone.0109950 Abstract • Figures |
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