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谭蔚泓综述：Cell-SELEX-based aptamer-conjugated nanomaterials
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文题：Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy 作者：Hong-Min Meng, Ting Fu, Xiao-Bing Zhang and Weihong Tan Natl Sci Rev, 2015, 2 (1): 71-84. doi:10.1093/nsr/nwv001 全文链接: http://nsr.oxfordjournals.org/content/2/1/71.full 摘要：Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic evolution of ligands by exponential enrichment), have recently attracted significant attention in the field of early detection and treatment of cancer based on their numerous merits, such as high affinity, high specificity, small size, little immunogenicity, stable structures, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric nanoparticles. We discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with different nanomaterials. 关键词：aptamer, cell-SELEX, nanomaterial, cancer cells, cancer diagnosis and therapy |
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2016-10-18 12:26:41, 2.96 M
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