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paperhunter: ½ð±Ò+10, ¹ÄÀø½»Á÷ 2016-10-01 15:29:22
Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice
×÷Õß:Xia, Z (Xia, Zhi)[ 1,2 ] ; Cholewa, J (Cholewa, Jason)[ 3 ] ; Zhao, Y (Zhao, Yan)[ 1 ] ; Yang, YQ (Yang, Yue-Qin)[ 2 ] ; Shang, HY (Shang, Hua-Yu)[ 4 ] ; Guimaraes-Ferreira, L (Guimaraes-Ferreira, Lucas)[ 5 ] ; Naimo, MA (Naimo, Marshall Alan)[ 6 ] ; Su, QS (Su, Quan-Sheng)[ 7 ] ; Zanchi, NE (Zanchi, Nelo Eidy)[ 8,9 ]
²é¿´ ResearcherID ºÍ ORCID
NUTRIENTS
¾í: 8  ÆÚ: 5
ÎÄÏ׺Å: 246
DOI: 10.3390/nu8050246
³ö°æÄê: MAY 2016
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Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1 (R) mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and signaling proteins involved in protein synthesis and degradation. The results show that both 8 weeks of leucine supplementation and aerobic training elevated the activity of mTOR (mammalian target of rapamycin) and its downstream target p70S6K and 4E-BP1, inhibited the ubiquitin-proteasome system, and increased fiber cross-sectional area (CSA) in white gastrocnemius muscle. Moreover, leucine supplementation in combination with exercise demonstrated more significant effects, such as greater CSA, protein content and altered phosphorylation (suggestive of increased activity) of protein synthesis signaling proteins, in addition to lower expression of proteins involved in protein degradation compared to leucine or exercise alone. The current study shows moderate aerobic training combined with 5% leucine supplementation has the potential to increase muscle size in fast-twitch skeletal muscle during aging, potentially through increased protein synthesis and decreased protein breakdown.
¹Ø¼ü´Ê
×÷Õ߹ؼü´Ê:leucine-rich diet; aerobic exercise; aging; protein metabolism
KeyWords Plus:MUSCLE PROTEIN-SYNTHESIS; HUMAN SKELETAL-MUSCLE; CHAIN AMINO-ACIDS; RESISTANCE EXERCISE; ENDURANCE EXERCISE; DIABETES-MELLITUS; OLDER-PEOPLE; EXPRESSION; RATS; SARCOPENIA
×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Zanchi, NE (ͨѶ×÷Õß)
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        Fed Univ Maranhao UFMA, Dept Phys Educ, BR-65020070 Sao Luis, MA, Brazil.
ͨѶ×÷ÕßµØÖ·: Zanchi, NE (ͨѶ×÷Õß)
              Lab Cellular & Mol Biol Skeletal Muscle LABCEMME, BR-65020070 Sao Luis, MA, Brazil.
µØÖ·:
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 1 ] Jinggangshan Univ, Coll Phys Educ, Exercise Physiol & Biochem Lab, Jian 343009, Jiangxi, Peoples R China
              [ 2 ] Wuhan Sports Univ, Exercise Intervent & Hlth Promot Hubei Prov Syner, Wuhan 430079, Peoples R China
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 3 ] Coastal Carolina Univ, Dept Kinesiol, Conway, SC 29528 USA
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 4 ] Beijing Sport Univ, Dept Exercise Physiol, Exercise Physiol Lab, Beijing 100084, Peoples R China
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 5 ] Univ Fed Espirito Santo, Ctr Phys Educ & Sports, Muscle Physiol & Human Performance Res Grp, BR-29075810 Vitoria, ES, Brazil
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 6 ] W Virginia Univ, Div Exercise Physiol, Sch Med, Morgantown, WV 26506 USA
              [ 7 ] Chengdu Sport Univ, Dept Sports Med, Chengdu 610041, Peoples R China
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 8 ] Fed Univ Maranhao UFMA, Dept Phys Educ, BR-65020070 Sao Luis, MA, Brazil
              [ 9 ] Lab Cellular & Mol Biol Skeletal Muscle LABCEMME, BR-65020070 Sao Luis, MA, Brazil
µç×ÓÓʼþµØÖ·:zhixia.ep@hotmail.com; jcholewa@coastal.edu; baihu0098@163.com; yangyueqin226@163.com; santanasan@163.com; lgtrainer@yahoo.com.br; man03e@my.fsu.edu; sqs111@126.com; neloz@ig.com.br
»ù½ð×ÊÖúÖÂл
»ù½ð×ÊÖú»ú¹¹        ÊÚȨºÅ
Jiangxi Province Science Foundation for Youths        
20142BAB215048
Scientific Research Foundation for PhD in Jinggangshan University        
JZB15014
²é¿´»ù½ð×ÊÖúÐÅÏ¢   
³ö°æÉÌ
MDPI AG, POSTFACH, CH-4005 BASEL, SWITZERLAND
Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Nutrition & Dietetics
Web of Science Àà±ð:Nutrition & Dietetics
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍ:Article
ÓïÖÖ:English
Èë²ØºÅ: WOS:000378780900007
ISSN: 2072-6643
ÆÚ¿¯ÐÅÏ¢
Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®
ÆäËûÐÅÏ¢
IDS ºÅ: DP8XI
Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 57
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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3Â¥: Originally posted by С·²ÏÂɽ at 2016-10-01 15:33:50
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