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Table of Contents

  
  Foreword, Pages v-vii, Neal L. Benowitz
  
  List of Contributors, Pages ix-xi, John W. Gorrod, Peyton Jacob III
  
  Chapter 1 - Pharmacological significance of nicotine, Pages 1-11, Edward F. Domino

  
  Chapter 2 - Biosynthesis of nicotine and related compounds, Pages 13-44, Lowell Bush, Walter P. Hempfling, Harold Burton

  
Chapter 3 - Biotransformation of nicotine in mammalian systems, Pages 45-67, John W. Gorrod, Georg Schepers

  
  Chapter 4 - Chemical properties of nicotine and other tobacco-related compounds, Pages 69-147, Peter A. Crooks

  
  Chapter 5 - The physical chemistry of nicotine, Pages 149-190, Joseph L. Banyasz

  
  Chapter 6 - Use of gas chromatographic and mass spectrometric techniques for the determination of nicotine and its metabolites, Pages 191-224, Peyton Jacob III, Gary D. Byrd

  
Chapter 7 - Use of high-performance liquid chromatographic-mass spectrometric (LC-MS) techniques for the determination of nicotine and its metabolites, Pages 225-264, Peter A. Crooks, Gary D. Byrd

  
  Chapter 8 - Use of immunoassay techniques for the determination of nicotine and its metabolites, Pages 265-283, John J. Langone, Hilda B. Gjika, Helen Van Vunakis

  
Chapter 9 - Determination of nicotine in tobacco, tobacco processing environments and tobacco products, Pages 285-391, Michael F. Borgerding, Thomas A. Perfetti, Suresh Ralapati

  
Chapter 10 - Determination of nicotine in pharmaceutical products and dietary sources, Pages 393-420, Donald E. Leyden, Erich Leitner, Barbara Siegmund

  
  Chapter 11 - Nitrosamines derived from nicotine and other tobacco alkaloids, Pages 421-488, Stephen S. Hecht, Anthony R. Tricker

  
  Chapter 12 - Determination of nicotine in mainstream and sidestream cigarette smoke, Pages 489-529, Klaus Rustemeier, Jean-Jacques Piad¨¦

  
  Chapter 13 - Nicotine in environmental tobacco smoke, Pages 531-581, Michael W. Ogden, Roger A. Jenkins

  
  Chapter 14 - Determination of nicotine and its metabolites in biological fluids: In vivo studies, Pages 583-643, Riley A. Davis, Margareta Curvall

  
  Chapter 15 - Determination of nicotine and its metabolites in biological fluids: In vitro studies, Pages 645-668, Mui C. Tsai, John W. Gorrod

  
  Chapter 16 - Uses and abuses of cotinine as a marker of tobacco smoke exposure, Pages 669-719, Peter N. Lee

  
  Index, Pages 721-758, John W. Gorrod, Peyton Jacob III
  

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