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[资源] Modified Nucleic Acids

Modified Nucleic Acids
By Kazuhiko Nakatani, Yitzhak Tor
Springer
2016
ISBN: 3319271091

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Table of contents (12 chapters)

      Emissive 5-Substituted Uridine Analogues
      Fin, Andrea (et al.)
      Pages 1-26

      Fluorescent Purine Nucleosides and Their Applications
      Saito, Yoshio (et al.)
      Pages 27-61

      Thiazole Orange-Tethered Nucleic Acids and ECHO Probes for Fluorometric Detection of Nucleic Acids
      Okamoto, Akimitsu
      Pages 63-81

      Synthetic Wavelength-Shifting Fluorescent Probes of Nucleic Acids
      Schwechheimer, Christian (et al.)
      Pages 83-100

      DNA-Assisted Multichromophore Assembly
      Takada, Tadao (et al.)
      Pages 101-121

      Polymerase Synthesis of Base-Modified DNA
      Dadová, Jitka (et al.)
      Pages 123-144

      Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications
      Sakamoto, Takashi (et al.)
      Pages 145-157

      Site-Directed Spin Labeling for EPR Studies of Nucleic Acids
      Shelke, Sandip A. (et al.)
      Pages 159-187

      Non-covalent Modification of Double-Stranded DNA at the Mismatch and Bulged Site
      Dohno, Chikara (et al.)
      Pages 189-207

      2′,4′-Bridged Nucleic Acids for Targeting Double-Stranded DNA
      Hari, Yoshiyuki (et al.)
      Pages 209-219

      Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-Oxoguanine
      Sasaki, Shigeki (et al.)
      Pages 221-248

      Genetic Alphabet Expansion by Unnatural Base Pair Creation and Its Application to High-Affinity DNA Aptamers
      Kimoto, Michiko (et al.)
      Pages 249-268