| 查看: 2249 | 回复: 9 | ||
试炼LHQ银虫 (小有名气)
|
[求助]
急求3-氨基丁醇工艺生产合成路线 已有2人参与
|
| 因为这两天需要做几百克3-氨基丁醇，急求各位大神一个工艺生产合成路线@小_包子 |
回复此楼» 猜你喜欢
华中科技大学 化学与化工学院 国家级青年人才诚招 2027年博士
已经有0人回复
-
中国地质大学（武汉）3D打印微纳光刻方向招收申请考核博士生
已经有20人回复
-
物理化学论文润色/翻译怎么收费?
已经有89人回复
-
美国北卡罗莱纳州立大学Dr Jian Zhang生物材料及精准药物递送实验室诚招博士后
已经有0人回复
-
求一本Common Fragrance and Flavor Materials电子书籍！
已经有1人回复
-
过均质机之前的硅油乳液，需不需要做到离心不分层？
已经有0人回复
-
【2026年粤港澳大湾区高价值知识产权培育布局大赛】散金币！
已经有1人回复
-
意大利帕多瓦大学化学系Movilli课题组招收CSC博士生
已经有0人回复
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
2楼2016-07-28 08:15:51
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
3楼2016-07-28 08:17:50
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
4楼2016-07-28 08:17:57
5楼2016-07-29 07:52:20
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
6楼2016-07-29 13:38:40
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
7楼2016-07-29 13:38:55
bysjj888
金虫 (小有名气)
- 应助: 22 (小学生)
- 金币: 1214.4
- 红花: 4
- 帖子: 141
- 在线: 88.6小时
- 虫号: 594791
- 注册: 2008-09-07
- 性别: GG
- 专业: 有机合成
【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:46
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:46
| General Procedure for the Synthesis of Compounds Starting from β-Amino Acids.; A solution of borane:tetrahydrofurane complex (1M, 3-4 mL per mmol=3-11 equiv. of β-amino acid) was added dropwise over a period of 1 hour to a cold (0° C.) suspension of beta amino acid (1 equiv.) in THF (1 mL per mmol). The mixture was stirred 20 minutes at room temperature at the end of the addition. It was then heated at reflux for 22 hours. The mixture was then cooled to 0° C.; and methanol (2 mL per mmol) was added over a period of 30 minutes. The mixture was then heated at reflux for 20 minutes and concentrated to a thick oil. The oil was co-evaporated with methanol (3.x.200 mL). The solid obtained was dried in vacuo to afford the coresponding 3-substituted 3-amino-1-propanol derivative as a white waxy solid (quantitative yield). An aqueous solution of HBr (48percent, 2 mL per equiv. of the alcohol) was added slowly to a flask containing a 3-substituted 3-amino-1-propanol (1 equilv.). The mixture was heated at reflux for 6 hours, and then concentrated to dryness. The crude material was used directly in the next step. The 1-substituted 3-bromo-1-propylamine hydrobromide (obtained in step 2) was added to a solution of sodium sulfite (1.0 equiv. of the 1-substituted 3-bromo-1-propylamine) in water and 1,4-dioxane. The mixture was heated under reflux for 6 h then concentrated to dryness. The residual material was treated with concentrated HCl. The inorganic material was removed by filtration; and the filtrate was treated ethanol, causing precipitation of the corresponding sulfonic acid. The crude sulfonic acid was suspended in ethanol and the mixture was heated at reflux for 1 hour. After cooling to room temperature, the solid material was collected by filtration, rinsed with ethanol and dried overnight in the vacuum oven at 60° C., giving the corresponding 3-substituted 3-amino-1-propanesulfonic acid as a fine white crystalline solid. 这个或许对你有用 |
8楼2016-07-29 16:58:55
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
9楼2016-07-30 07:32:05
115993564
铁杆木虫 (著名写手)
- 应助: 5 (幼儿园)
- 金币: 6842.4
- 散金: 1675
- 红花: 3
- 帖子: 2156
- 在线: 480.6小时
- 虫号: 671720
- 注册: 2008-12-10
- 性别: GG
- 专业: 药物化学
10楼2018-06-26 17:03:53