| 查看: 2065 | 回复: 9 | ||
试炼LHQ银虫 (小有名气)
|
[求助]
急求3-氨基丁醇工艺生产合成路线 已有2人参与
|
| 因为这两天需要做几百克3-氨基丁醇，急求各位大神一个工艺生产合成路线@小_包子 |
回复此楼» 猜你喜欢
核磁分析软件MestReNova打开文件时报错
已经有0人回复
-
在职博后不能申请博后基金了，那么在职博后意义何在？
已经有2人回复
-
物理化学论文润色/翻译怎么收费?
已经有293人回复
-
MRS Communications 期刊啥时候有正式页码
已经有1人回复
-
青岛大学化学化工学院分子测量学研究院2026年招收博士研究生
已经有0人回复
-
香港科技大学（广州）诚招电催化方向博士生（2026秋入学）
已经有0人回复
-
双一流高校南京林业大学材料学院招收2026年申请考核博士生
已经有0人回复
-
国家双一流建设高校——2026南京林业大学化学工程学院招收申请考核博士生1名
已经有0人回复
-
法国斯特拉斯堡大学招CSC攻读博士-超分子化学、高分子科学和有机化学合成背景
已经有0人回复
-
求助Cu2+1O的CIF文件(PDF: 05-0667)
已经有1人回复
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
2楼2016-07-28 08:15:51
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
3楼2016-07-28 08:17:50
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
4楼2016-07-28 08:17:57
5楼2016-07-29 07:52:20
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
6楼2016-07-29 13:38:40
试炼LHQ
银虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 246.2
- 散金: 851
- 帖子: 295
- 在线: 87.3小时
- 虫号: 1467576
- 注册: 2011-10-30
- 性别: GG
- 专业: 药物化学
7楼2016-07-29 13:38:55
bysjj888
金虫 (小有名气)
- 应助: 22 (小学生)
- 金币: 1287.8
- 红花: 4
- 帖子: 139
- 在线: 88.2小时
- 虫号: 594791
- 注册: 2008-09-07
- 性别: GG
- 专业: 有机合成
【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:46
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:46
| General Procedure for the Synthesis of Compounds Starting from β-Amino Acids.; A solution of borane:tetrahydrofurane complex (1M, 3-4 mL per mmol=3-11 equiv. of β-amino acid) was added dropwise over a period of 1 hour to a cold (0° C.) suspension of beta amino acid (1 equiv.) in THF (1 mL per mmol). The mixture was stirred 20 minutes at room temperature at the end of the addition. It was then heated at reflux for 22 hours. The mixture was then cooled to 0° C.; and methanol (2 mL per mmol) was added over a period of 30 minutes. The mixture was then heated at reflux for 20 minutes and concentrated to a thick oil. The oil was co-evaporated with methanol (3.x.200 mL). The solid obtained was dried in vacuo to afford the coresponding 3-substituted 3-amino-1-propanol derivative as a white waxy solid (quantitative yield). An aqueous solution of HBr (48percent, 2 mL per equiv. of the alcohol) was added slowly to a flask containing a 3-substituted 3-amino-1-propanol (1 equilv.). The mixture was heated at reflux for 6 hours, and then concentrated to dryness. The crude material was used directly in the next step. The 1-substituted 3-bromo-1-propylamine hydrobromide (obtained in step 2) was added to a solution of sodium sulfite (1.0 equiv. of the 1-substituted 3-bromo-1-propylamine) in water and 1,4-dioxane. The mixture was heated under reflux for 6 h then concentrated to dryness. The residual material was treated with concentrated HCl. The inorganic material was removed by filtration; and the filtrate was treated ethanol, causing precipitation of the corresponding sulfonic acid. The crude sulfonic acid was suspended in ethanol and the mixture was heated at reflux for 1 hour. After cooling to room temperature, the solid material was collected by filtration, rinsed with ethanol and dried overnight in the vacuum oven at 60° C., giving the corresponding 3-substituted 3-amino-1-propanesulfonic acid as a fine white crystalline solid. 这个或许对你有用 |
8楼2016-07-29 16:58:55
keailinger
至尊木虫 (文坛精英)
- TEPI: 24
- 应助: 872 (博后)
- 贵宾: 0.322
- 金币: 11261.1
- 散金: 12142
- 红花: 299
- 沙发: 29
- 帖子: 11216
- 在线: 951.5小时
- 虫号: 567069
- 注册: 2008-06-01
- 性别: GG
- 专业: 有机合成
9楼2016-07-30 07:32:05
115993564
铁杆木虫 (著名写手)
- 应助: 5 (幼儿园)
- 金币: 6842.4
- 散金: 1675
- 红花: 3
- 帖子: 2156
- 在线: 480.6小时
- 虫号: 671720
- 注册: 2008-12-10
- 性别: GG
- 专业: 药物化学
10楼2018-06-26 17:03:53