【答案】应助回帖

» 猜你喜欢

天津工业大学郑柳春团队长期招化学化工、高分子化学或有机合成方向的博士生已经有0人回复
天津工业大学郑柳春团队长期招化学化工、高分子化学或有机合成方向的博士生已经有0人回复
高分子科学论文润色/翻译怎么收费? 已经有161人回复
Coordination Chemistry Reviews 已经有1人回复
同济大学张海军教授2026年度博士招生已经有1人回复
同济大学张海军教授2026年度博士招生已经有0人回复
请问现在还有电池材料方向的博导招人吗已经有3人回复

1楼2016-07-27 22:06:09

keailinger

至尊木虫 (文坛精英)

TEPI: 24
应助: 872 (博后)
贵宾: 0.322
金币: 11261.1
散金: 12142
红花: 299
沙发: 29
帖子: 11216
在线: 951.5小时
虫号: 567069
注册: 2008-06-01
性别: GG
专业: 有机合成

你这个是手性产品吧，你要消旋体？

不坠青云之志

2楼2016-07-28 08:15:51

试炼LHQ

银虫 (小有名气)

应助: 0 (幼儿园)
金币: 246.2
散金: 851
帖子: 295
在线: 87.3小时
虫号: 1467576
注册: 2011-10-30
性别: GG
专业: 药物化学

引用回帖:

2楼: Originally posted by keailinger at 2016-07-28 08:15:51
你这个是手性产品吧，你要消旋体？

我是手性的原料，做出来是手性产物

发自小木虫Android客户端

3楼2016-07-28 08:17:50

keailinger

至尊木虫 (文坛精英)

TEPI: 24
应助: 872 (博后)
贵宾: 0.322
金币: 11261.1
散金: 12142
红花: 299
沙发: 29
帖子: 11216
在线: 951.5小时
虫号: 567069
注册: 2008-06-01
性别: GG
专业: 有机合成

【答案】应助回帖

★ ★ ★ ★ ★
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:30

3-氨基丁酸与氯化亚砜反应后，加乙醇成酯，然后硼氢化钾还原。得到3-氨基丁醇。

赞一下(1人)

不坠青云之志

4楼2016-07-28 08:17:57

woconan

银虫 (小有名气)

应助: 0 (幼儿园)
金币: 208.7
散金: 10
红花: 1
帖子: 120
在线: 86小时
虫号: 572775
注册: 2008-06-12
专业: 有机合成

你原料是啥

发自小木虫IOS客户端

5楼2016-07-29 07:52:20

试炼LHQ

银虫 (小有名气)

应助: 0 (幼儿园)
金币: 246.2
散金: 851
帖子: 295
在线: 87.3小时
虫号: 1467576
注册: 2011-10-30
性别: GG
专业: 药物化学

引用回帖:

4楼: Originally posted by keailinger at 2016-07-28 08:17:57
3-氨基丁酸与氯化亚砜反应后，加乙醇成酯，然后硼氢化钾还原。得到3-氨基丁醇。

我是用硼氢化钠还原的，但是提取时出问题，产物水溶性好，而且还原后处理有好多盐，除不掉

6楼2016-07-29 13:38:40

试炼LHQ

银虫 (小有名气)

应助: 0 (幼儿园)
金币: 246.2
散金: 851
帖子: 295
在线: 87.3小时
虫号: 1467576
注册: 2011-10-30
性别: GG
专业: 药物化学

引用回帖:

5楼: Originally posted by woconan at 2016-07-29 07:52:20
你原料是啥

3-氨基丁酸

7楼2016-07-29 13:38:55

bysjj888

金虫 (小有名气)

应助: 22 (小学生)
金币: 1287.8
红花: 4
帖子: 139
在线: 88.2小时
虫号: 594791
注册: 2008-09-07
性别: GG
专业: 有机合成

【答案】应助回帖

★ ★ ★ ★ ★
感谢参与，应助指数 +1
试炼LHQ(流浪南昌代发): 金币+5, 感谢回帖 2016-08-08 14:49:46

General Procedure for the Synthesis of Compounds Starting from β-Amino Acids.; A solution of borane:tetrahydrofurane complex (1M, 3-4 mL per mmol=3-11 equiv. of β-amino acid) was added dropwise over a period of 1 hour to a cold (0° C.) suspension of beta amino acid (1 equiv.) in THF (1 mL per mmol). The mixture was stirred 20 minutes at room temperature at the end of the addition. It was then heated at reflux for 22 hours. The mixture was then cooled to 0° C.; and methanol (2 mL per mmol) was added over a period of 30 minutes. The mixture was then heated at reflux for 20 minutes and concentrated to a thick oil. The oil was co-evaporated with methanol (3.x.200 mL). The solid obtained was dried in vacuo to afford the coresponding 3-substituted 3-amino-1-propanol derivative as a white waxy solid (quantitative yield). An aqueous solution of HBr (48percent, 2 mL per equiv. of the alcohol) was added slowly to a flask containing a 3-substituted 3-amino-1-propanol (1 equilv.). The mixture was heated at reflux for 6 hours, and then concentrated to dryness. The crude material was used directly in the next step. The 1-substituted 3-bromo-1-propylamine hydrobromide (obtained in step 2) was added to a solution of sodium sulfite (1.0 equiv. of the 1-substituted 3-bromo-1-propylamine) in water and 1,4-dioxane. The mixture was heated under reflux for 6 h then concentrated to dryness. The residual material was treated with concentrated HCl. The inorganic material was removed by filtration; and the filtrate was treated ethanol, causing precipitation of the corresponding sulfonic acid. The crude sulfonic acid was suspended in ethanol and the mixture was heated at reflux for 1 hour. After cooling to room temperature, the solid material was collected by filtration, rinsed with ethanol and dried overnight in the vacuum oven at 60° C., giving the corresponding 3-substituted 3-amino-1-propanesulfonic acid as a fine white crystalline solid. 这个或许对你有用

8楼2016-07-29 16:58:55