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lyf1023

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专业: 生物化学

[交流] Postdoctoral Positions in Quantitative Biology at Harvard Medical School 已有3人参与

In January 2017, our quantitative biology lab will start up in the Department of Systems Biology at
Harvard Medical School. Applicants are welcome from a broad spectrum of backgrounds ranging
from the biological sciences to math / physics / engineering disciplines. The approach of our lab
relies on the close coordination and mutual feedback between experimental and theoretical
efforts. We are searching both experienced experimentalists, as well as theorists interested in
starting to work in the wet lab. While not a prerequisite, experimental experience in either
microbiology, fly genetics or molecular cloning will be considered very positively.
We are looking for creative, open-minded individuals, interested in venturing off the beaten track
and possessing the determination required for withstanding the ups and downs of doing science
and for bringing their ideas to fruition.
The start date of the position is flexible, but there is some preference for the beginning of 2017.
We offer competitive remuneration and are an equal opportunity employer. All qualified applicants
will receive consideration for employment without regard to race, color, religion, sex, national
origin, disability status, protected veteran status, gender identity, sexual orientation or any other
characteristic protected by law.
Our Research Interests
The complexity and heterogeneity of biological systems are fundamental obstacles that must be
overcome for achieving a more quantitative and predictive understanding of physiology and
phenotypes on the cellular or organism scale. Such a level of understanding has remained largely
elusive in biology, despite the extraordinary level of detail to which molecular interactions have
been characterized over the past decades, as it often remains unclear how to harness detailed
molecular knowledge to achieve this goal.
In our lab, we try to tackle these challenges by identifying phenotypic patterns that can guide us
in decoding the underlying molecular mechanisms and principles, which govern the behavior of
complex biological systems. Our approach relies on the close coordination and mutual feedback
between experimental and theoretical efforts and we combine careful characterization of
physiology, genetic perturbations, omics technology and theoretical models.
Fundamental biological questions that we are interested in include the role of metabolic strategies
during growth and adaptation, tradeoffs between competing evolutionary objectives of
microorganisms and how cells achieve homeostasis of cell size, cell number and cellular
composition, as well as the breakdown of these mechanisms in disease. We use the well?characterized model organisms Escherichia coli and Drosophila melanogaster to address such
questions.
Please contact:
Markus Basan, markus@hms.harvard.edu
Current address: Institute of Molecular Systems Biology, ETH Zurich
HPT D 73, Auguste-Piccard-Hof 1, 8093 Zürich, Switzerland, office: +41 44 633 4052

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