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[求助]
【求助】群体遗传学小白求助
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最近刚接触群体遗传学，对EHH，REHH概念不太清楚，求论坛大神通俗版解释 上传了是看的文献中两张figure 纠结了很久，具体要怎么解读~ In the Chinese population, the decay of haplotype homozygosity for the C allele (marked with red) occurs much more slowly than for the T allele (blue), suggesting potential positive selection acting on haplotypes containing this allele. In Europeans and Africans, the decay of haplotype homozygosity for the C allele issimilar to the T allele。 The decay of EHH for the C allele and T allele is not significant in the three populations (P > 0.05). However, REHH results revealed that the haplotypes with the C allele decay significantly slower than the haplotypes with the T allele (P = 0.033) in the Chinese population. REHH results are not statistically significant for the C allele and T allele in Europeans and Africans。 Haplotype bifurcation graphs show that the bifurcation of haplotypes is also slower for the C allele (a) of rs31480 compared with the T allele (b) in the Chinese population. In Europeans (CEU, c, d) and Africans (YRI, e, f), bifurcation of haplotypes for the C allele and T allele are comparable, indicating no recent positive selection on rs31480 in Europeans and Africans. The haplotype thicknesses represent the haplotype frequency. Haplotypes with unusually high EHH and a high population frequency (thicknesses) suggest the presence of recent positive selection that drives rapid increase in frequency of new variants or haplotypes in the population. Unusually long and thick haplotypes are observed for the C allele of rs31480 in Chinese (a), but not for the T allele, indicating recent positive selection of the C allele.  14160157.png  43756964.png |
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