| ²é¿´: 842 | »Ø¸´: 1 | |||
linlin7
|
[½»Á÷]
¡¾¼¼ÊõÊÓÆµ¡¿DOW»¯Ñ§Æ·°²È«ÆÀ¼ÛÖ®£º²ÉÓÃQSAR/PBPKÔ¤²â»¯ºÏÎïÔÚÌåÄÚ±©Â¶Á¿ ÒÑÓÐ1È˲ÎÓë
|
|
¡¾¼¼ÊõÊÓÆµ¡¿DOW»¯Ñ§Æ·°²È«ÆÀ¼ÛÖ®£º²ÉÓÃQSAR/PBPKÔ¤²â»¯ºÏÎïÔÚÌåÄÚ±©Â¶Á¿ µ¼¶Á£º 2016Äê6ÔÂ16ÈÕ£¬ÃÀ¹ú¶¾Àíѧ»áÉúÎィģ×é×éÖ¯ÁË¡°»¯Ñ§Æ·°²È«ÆÀ¼ÛÖ®£º²ÉÓÃQSAR/PBPKÔ¤²â»¯ºÏÎïÔÚÌåÄÚ±©Â¶Á¿¡±Saying I do to the QSAR/PBPK marriage in GastroPlus to predict chemical exposure for safety evaluationµÄÍøÂçÑÐÌֻᡣ »áÒéÑûÇëÁËÃÀ¹úSimulations Plus¹«Ë¾ºÍDow Chemical£¨ÌÕÊÏ»¯Ñ§£©µÄר¼Ò½²½âÈçºÎÔ¤²â»¯Ñ§Æ·ÔÚÌåÄڵı©Â¶Á¿¡£ ±¨¸æÈË£º John DiBella, Simulations Plus Fagen Zhang and Leah Luna£¬The Dow Chemical Company ÊÓÆµÏÂÔØÁ´½Ó£ºhttp://pan.baidu.com/s/1c1HBb4OÃÜÂ룺aqi4 ¿Î¼þPDF¿Î¼þÏÂÔØÁ´½Ó£ºhttp://pan.baidu.com/s/1bNeIRW ¹ØÓÚDow Chemical£º ÌÕÊÏÊÇÒ»¼Ò¶àÔª»¯µÄ»¯Ñ§¹«Ë¾£¬ÔËÓÿÆÑ§ºÍ¼¼ÊõµÄÁ¦Á¿£¬²»¶Ï´´Ð£¬ÎªÈËÀà´´Ôì¸üÃÀºÃµÄÉú»î¡£¹«Ë¾Í¨¹ý»¯Ñ§¡¢ÎïÀíºÍÉúÎï¿ÆÑ§µÄÓлú½áºÏÀ´Íƶ¯´´Ðºʹ´Ôì¼ÛÖµ£¬È«Á¦½â¾öµ±½ñÊÀ½çµÄÖî¶àÌôÕ½£¬ÈçÂú×ãÇå½àË®µÄÐèÇó¡¢ÊµÏÖ¿ÉÔÙÉúÄÜÔ´µÄÉú²úºÍ½ÚÔ¼¡¢Ìá¸ßÅ©×÷Îï²úÁ¿µÈ¡£ ÌÕÊÏÒÔÆäÒ»Ì廯¡¢Êг¡Çý¶¯ÐÍ¡¢ÐÐÒµÁìÏȵÄÌØÖÖ»¯Ñ§¡¢¸ßвÄÁÏ¡¢Å©Òµ¿ÆÑ§ºÍËÜÁϵÈÒµÎñ£¬ÎªÈ«ÇòÔ¼180¸ö¹ú¼ÒºÍµØÇøµÄ¿Í»§ÌṩÖÖÀà·±¶àµÄ²úÆ·¼°·þÎñ£¬Ó¦ÓÃÓÚ°ü×°¡¢µç×Ó²úÆ·¡¢Ë®´¦Àí¡¢Í¿ÁϺÍũҵµÈ¸ßËÙ·¢Õ¹µÄÊг¡¡£2014Ä꣬ÌÕÊÏÄêÏúÊ۶¹ý580ÒÚÃÀÔª£¬ÔÚÈ«ÇòÓµÓÐÔ¼53,000ÃûÔ±¹¤£¬ÔÚ35¸ö¹ú¼ÒºÍµØÇøÔËÓª201¼Ò¹¤³§£¬²úÆ·´ï6,000¶àÖÖ¡£ ÔçÔÚÉÏÊÀ¼Í30Äê´ú£¬ÌÕÊϾÍÒѾÔÚÖйú¿ªÕ¹ÒµÎñ¡£Ä¿Ç°£¬´óÖлªÇøÊÇÌÕÊÏÈ«ÇòµÚ¶þ´ó¹ú¼ÊÊг¡£¬ÌÕÊÏÔÚÕâÀïµÄ×ÜͶ×ʶî´ï12ÒÚÃÀÔª£¬2014ÄêÏúÊÛ¶îΪ43ÒÚÃÀÔª¡£ ¹ØÓÚSimulations Plus£º רעÓÚÎªÖÆÒ©¡¢ÉúÎï¼¼ÊõÁìÓòÌṩ¼ÓËÙÒ©ÎïÑз¢½ø³Ì¡¢½ÚÊ¡³É±¾¼°Ìá¸ßЧÂʵĽâ¾ö·½°¸¡£Ö÷Òª²úÆ·--ADMET Predictor, GastroPlus£¬MedChem Studio, DDDPlusµÃµ½Òµ½ç¸ß¶ÈÍÆ³ç¡£ FDA, CFDA, EMA, ÈÕ±¾ºñÉúÊ¡£¬ÃÀ¹úEPAÅ·ÃË»¯Ñ§Æ·¹ÜÀí¾ÖECHA, ÃÀ¹ú¹ú¼Ò°©Ö¢Ñо¿ËùNCI¡£È«ÇòTOP20µÄÖÆÒ©ÆóÒµ¶¼ÊÇSimulations PlusµÄÓû§£¬ÈçRoche, GSK, Novartis, Eli Lilly, Pfizer, Johnson & Johnson, MerckµÈ¡£ ¹ØÓÚSOT£º Founded in 1961, the Society of Toxicology (SOT) is a professional and scholarly organization of scientists from academic institutions, government, and industry representing the great variety of scientists who practice toxicology in the US and abroad. The Society¡¯s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology. SOT operates under the guiding principles of: Serving the needs of the scientific discipline and our members to enhance human, animal, and environmental health Life-long learning and intellectual scientific stimulation Diversity of representation in all activities of the Society Integrity |
» ±¾Ìû¸½¼þ×ÊÔ´Áбí
-
»¶Ó¼à¶½ºÍ·´À¡£ºÐ¡Ä¾³æ½öÌṩ½»Á÷ƽ̨£¬²»¶Ô¸ÃÄÚÈݸºÔð¡£
±¾ÄÚÈÝÓÉÓû§×ÔÖ÷·¢²¼£¬Èç¹ûÆäÄÚÈÝÉæ¼°µ½ÖªÊ¶²úȨÎÊÌ⣬ÆäÔðÈÎÔÚÓÚÓû§±¾ÈË£¬Èç¶Ô°æÈ¨ÓÐÒìÒ飬ÇëÁªÏµÓÊÏ䣺xiaomuchong@tal.com - ¸½¼þ 1 : Dow-QSAR&PBPK_to_predict_chemical_exposure_for_safety_evaluation20160616.pdf
2016-07-06 12:34:26, 4.6 M
» ²ÂÄãϲ»¶
Ò»Ö¾Ô¸±±¾©Àí¹¤´óѧ±¾¿Æ211²ÄÁϹ¤³Ì294Çóµ÷¼Á
ÒѾÓÐ8È˻ظ´
349Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
329Çóµ÷¼Á
ÒѾÓÐ9È˻ظ´
Çóµ÷¼ÁÒ»Ö¾Ô¸Î人Àí¹¤´óѧ²ÄÁϹ¤³Ì£¨085601£©
ÒѾÓÐ9È˻ظ´
327Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
ÇóÊÕÁô
ÒѾÓÐ5È˻ظ´
375Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
340Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
298Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
085601²ÄÁϹ¤³ÌÕÒµ÷¼Á
ÒѾÓÐ9È˻ظ´
» ±¾Ö÷ÌâÏà¹ØÉ̼ÒÍÆ¼ö: (ÎÒÒ²ÒªÔÚÕâÀïÍÆ¹ã)
belladonae
½ð³æ (ÖøÃûдÊÖ)
ÉÙ½«
- PhEPI: 1
- Ó¦Öú: 189 (¸ßÖÐÉú)
- ½ð±Ò: 4739.5
- É¢½ð: 1508
- ºì»¨: 27
- Ìû×Ó: 2155
- ÔÚÏß: 1390.9Сʱ
- ³æºÅ: 467524
- ×¢²á: 2007-11-26
- ÐÔ±ð: MM
- רҵ: Ò©¼Áѧ
2Â¥2016-07-07 08:16:05















»Ø¸´´ËÂ¥