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表征多晶型的转变
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Many drugs are formulated as solids. Although convenient and compact, solid drug formulations can be problematic because the active pharmaceutical ingredient can exist in more than one thermodynamically or kinetically stable crystalline or amorphous form, and can interconvert between these forms during processing or storage. The ability of a compound to exist in different solid state forms (polymorphism) impacts the solubility, and thus the bioavailability, of the pharmaceutical. Interconversion from a more soluble to a less soluble form may occur during manufacture of the pure drug, during formulation processes, and after long-term storage, thereby changing the pharmaceutically-active properties of the final product. |
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- 附件 1 : 表征多晶形的转变.pdf
2016-07-04 16:19:44, 359.23 K
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