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透析膜的生物相容性研究
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| The interaction between biological tissues and artificial materials is becoming increasingly important in the field of biomedicine. Synthetic grafts are implanted in the body and different cells will be exposed to these foreign materials. The interactions between such synthetic vascular grafts and blood components (granulocytes and platelets) have successfully been investigated by using microcalorimetry. Another biocompatibility problem exists for hemodialysis membranes and blood. This application note deals with the microcalorimetric evaluation of the interactions between human granulocytes and different materials used for dialysis reported in detail by Monti, Ljunggren and co-workers . Granulocytes are characterised by a low basal metabolism and a large metabolic burst when exposed to foreign particles. The basal metabolism as well as the metabolism associated with phagocytosis was measured for granulocytes in contact with different materials. As shown here, the efficacy of different materials for use with living cells is easily monitored by using TAM. |
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2016-07-01 16:26:46, 501.96 K
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