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胃肠道和胰腺神经内分泌肿瘤细胞系的建立
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在innocentive.com上看到的一个挑战项目，肠道类癌或胰腺神经内分泌肿瘤细胞系 Intestinal Carcinoid and Pancreatic Neuroendocrine Tumor Cell Lines Needed – Year Two 一直想做，截至7月6日，时间紧，不知有没有在自己胃肠道类癌或胰腺神经内分泌肿瘤细胞系的？一方面是推荐，一方面是有些新方法想找实验室合作。 BACKGROUND The majority of neuroendocrine tumors can be divided into two classes: carcinoid and pancreatic neuroendocrine tumors. Carcinoid commonly refers to neuroendocrine tumors that originate in the gastrointestinal (GI) tract, lungs, appendix and thymus, although they can also occur in the lymph nodes, brain, bone, gonads (ovaries and testes) and skin. Carcinoid tumors are usually indolent (slow-growing) by nature and develop over the course of many years. However, aggressive, fast-growing forms of carcinoid cancer also exist. Neuroendocrine tumors are classified as rare cancers. Recent studies have determined that 4 to 5 out of every 100,000 people are diagnosed yearly with a neuroendocrine tumor and that there are over 100,000 people currently living with neuroendocrine tumors within the United States (Yao et al., 2009). For reasons not well understood, the incidence of these cancers is rising. Since most individuals with neuroendocrine tumors are asymptomatic until the tumors metastasize, the average time between tumor development and diagnosis is between 5 to 10 years (Vinik, 2008; Vinik et al., 2009). Survival rates for individuals with neuroendocrine cancer vary and depend on tumor type, location, extent of metastases, and many other factors. Currently, surgery is the only cure for localized tumors (those which have not spread) and there is no cure for metastatic neuroendocrine cancer (Yao, 2007). This Challenge is intended to encourage development of intestinal carcinoid and pancreatic neuroendocrine tumor cell lines. 我的邮箱是：agilebio@126.com  |
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