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[求助] 羟胺的PDE值为2微克/天，这是怎么计算出来的或者出自哪文献？已有1人参与

羟胺的PDE值为2微克/天，这是怎么计算出来的或者出自哪文献？

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szw303

铁虫 (正式写手)

应助: 78 (初中生)
金币: 1809.3
散金: 56
红花: 8
帖子: 358
在线: 456.8小时
虫号: 1497603
注册: 2011-11-18
专业: 有机合成

*** HEALTH HAZARD DATA ***

                     ** ACUTE TOXICITY DATA **

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Intraperitoneal
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106)  V.1- 1941-  Volume(issue)/page/year:
26,1448,1966

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Subcutaneous
SPECIES OBSERVED       : Rodent - rat
DOSE/DURATION          : 29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1- 1909/10-
Volume(issue)/page/year: 119,444,1957

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Intraperitoneal
SPECIES OBSERVED       : Rodent - mouse
DOSE/DURATION          : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1- 1909/10-
Volume(issue)/page/year: 165,30,1969

TYPE OF TEST          : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE    : Unreported
SPECIES OBSERVED       : Rodent - mouse
DOSE/DURATION          : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK)  V.1- 1947-  Volume(issue)/page/year:
6,160,1952

                        ** MUTATION DATA **

TYPE OF TEST          : Mutation in microorganisms
TEST SYSTEM          : Bacteria - Salmonella typhimurium
DOSE/DURATION          : 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1- 1969/70-
Volume(issue)/page/year: 4,286,1974

TYPE OF TEST          : DNA repair
TEST SYSTEM          : Bacteria - Salmonella typhimurium
DOSE/DURATION          : 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1- 1969/70-
Volume(issue)/page/year: 4,286,1974

TYPE OF TEST          : Mutation in microorganisms
TEST SYSTEM          : Bacteria - Escherichia coli
DOSE/DURATION          : 5 pph
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1- 1969/70-
Volume(issue)/page/year: 4,286,1974

TYPE OF TEST          : DNA damage
TEST SYSTEM          : Bacteria - Escherichia coli
DOSE/DURATION          : 50 mmol/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands)  V.1- 1947- Volume(issue)/page/year:
119,434,1966

TYPE OF TEST          : Mutation in microorganisms
TEST SYSTEM          : Bacteria - Bacillus subtilis
DOSE/DURATION          : 1 mol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States
of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 48,1796,1962

TYPE OF TEST          : DNA repair
TEST SYSTEM          : Bacteria - Bacillus subtilis
DOSE/DURATION          : 23 gm/L
REFERENCE :
MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964-  Volume(issue)/page/year: 16,165,1972

TYPE OF TEST          : Phage inhibition capacity
TEST SYSTEM          : Bacteria - Bacillus subtilis
DOSE/DURATION          : 1 mol/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1- 1963-
Volume(issue)/page/year: 22,338,1984