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¡¾·ÖÏí¡¿ÊéSystems Biology£ºPROPERTIES OF RECONSTRUCTED NETWORKS¡¾ÒÑËÑË÷ÎÞÖØ¸´¡¿
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¿ÊÍûºÃ¾ÃÁË£¬ ÖÕÓÚ¿´µ½£¬ Óë¾ý¹²Ïí£¬±ðÍüÆÀ¼Ûһϰ¡£¡°ÝÍÐ ºÇºÇ£¡ µç×ÓÊé¡¶Systems Biology£ºPROPERTIES OF RECONSTRUCTED NETWORKS¡· Contents Preface page ix 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 2 Basic Concepts in Systems Biology . . . . . . . . . . . . . . . . . . . . . . . . 12 PART I. RECONSTRUCTION OF BIOCHEMICAL NETWORKS 3 Metabolic Networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 4 Transcriptional Regulatory Networks . . . . . . . . . . . . . . . . . . . . . . . 54 5 Signaling Networks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 PART II. MATHEMATICAL REPRESENTATION OF RECONSTRUCTED NETWORKS 6 Basic Features of the Stoichiometric Matrix . . . . . . . . . . . . . . . . . . .89 7 Topological Properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 8 Fundamental Subspaces of S . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 9 The (Right) Null Space of S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 136 10 The Left Null Space of S . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 154 11 The Row and Column Spaces of S . . . . . . . . . . . . . . . . . . . . . . . . 170 PART III. CAPABILITIES OF RECONSTRUCTED NETWORKS 12 Dual Causality . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 13 Properties of Solution Spaces . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 14 Sampling Solution Spaces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228 15 Finding Functional States . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 244 16 Parametric Sensitivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265 17 Epilogue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282 APPENDIX A. Nomenclature and Abbreviations 287 APPENDIX B. E. coli Core Metabolic Network 294 Bibliography 299 Ãâ½ð±ÒÏÂÔØµØÖ· http://www.ebookee.com.cn/System ... Networks_11287.html ÓÐÉúÎïÐãÕʺŵÄÒ²¿ÉÒÔÈ¥ÄÇÀïÏÂÔØ http://www.bbioo.com/bbs/viewthr ... a=page%3D1#pid94001 |
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