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1. Cyclic cyanamides were incorporated providing 3b, 3c, and 3d in 40, 82, and 35% yields, respectively (entry 2¨C4). 2. Finally, the challenging terminal alkynenitrile 1c failed to react under these conditions¡£ 3. Efforts to replace the cyanamide substrate with an unactivated nitrile such as PhCN were ineffective as were 3-component cyclizations of 4-CH3PhCCH with either 2 equivalents of free nitriles (i.e., PhCN) or cyanamides (i.e., 2a). |
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