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Pharmacological Mechanisms in Alzheimer's Therapeutics
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Pharmacological Mechanisms in Alzheimer's Therapeutics by Claudio Cuello Springer Oct. 31, 2007 ISBN: 0387978798 Contents xi FOREWORDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v William H. Thies Theodore L. Sourkes PREFACE FROM THE EDITOR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix A. Claudio Cuello LIST OF CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv 1. OVERVIEW OF THE ALZHEIMER’S DISEASE PATHOLOGY AND POTENTIAL THERAPEUTIC TARGETS . . . . . . . . . . . . . 1 A. Claudio Cuello 2. TRIAL DESIGNS AND OUTCOMES TO MONITOR NOVEL THERAPEUTICS IN ALZHEIMER’S DISEASE . . . . . . . . . . . . 28 Serge Gauthier 3. THE PHARMACOLOGICAL TREATMENT OF ALZHEIMER’S DISEASE WITH CHOLINESTERASE INHIBITORS AND MEMANTINE . . . . . . . . . . . . . . . . . . 36 Gordon Keith Wilcock 4. M1 MUSCARINIC AGONISTS: A COMPREHENSIVE THERAPY AGAINST MAJOR HALLMARKS OF ALZHEIMER’S DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 Abraham Fisher 5. CHOLINERGIC NEURODEGENERATION IN ALZHEIMER’S DISEASE: BASIS FOR NERVE GROWTH FACTOR THERAPY. . . . . Ahmad Salehi, Alexander Kleshevnikov, and William C. Mobley 6. THE RATIONALE FOR GLUTAMATERGIC THERAPY IN ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . . . . . . . . . . . . 105 Paul T. Francis 7. SECRETASES AS PHARMACOLOGICAL TARGETS IN ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . . . . . . . . . . . . 113 Nigel M. Hooper and Emma R. L. C. Vardy 8. g-SECRETASE AS A TARGET FOR ALZHEIMER’S DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 Michael S. Wolfe 9. THE RATIONALE FOR AN IMMUNOLOGICAL APPROACH TO ALZHEIMER’S THERAPEUTICS . . . . . . . . 141 Dave Morgan 10. NEUROINFLAMMATION, ALZHEIMER DISEASE, AND OTHER AGING DISORDERS . . . . . . . . . . . . . . . . . . . . . 149 Edith G. McGeer and Patrick L. McGeer 11. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) AND DERIVED Ab42-LOWERING MOLECULES FOR TREATMENT AND PREVENTION OF ALZHEIMER’S DISEASE (AD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 Sascha Weggen, Eva Czirr, Stefanie Leuchtenberger, and Jason Eriksen 12. THE POTENTIAL APPLICATION OF ANTIOXIDANT AGENTS IN ALZHEIMER DISEASE THERAPEUTICS. . . . . 194 Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, and George Perry 13. APOLIPOPROTEIN E: A POTENT GENE-BASED THERAPEUTIC TARGET FOR THE TREATMENT OF SPORADIC ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . 212 Judes Poirier 14. TAU PATHOLOGY AS A TARGET IN ALZHEIMER’S THERAPEUTICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 Khalid Iqbal and Inge Grundke-Iqbal 15. DESIGN OF INHIBITORS OF AMYLOID-b MISFOLDING AND AGGREGATION FOR ALZHEIMER’S THERAPY . . . . 238 Lisbell D. Estrada, Cristian Lasagna, and Claudio Soto 16. POTENTIAL APPLICATIONS OF GLYCOSAMINOGLYCANRELATED COMPOUNDS IN ALZHEIMER’S DISEASE . . . . 255 Céline Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, and Barry D. Greenberg 17. MULTIFUNCTIONAL NEUROPROTECTIVE DRUGS FOR THE TREATMENT OF ALZHEIMER’S DISEASE. . . . . 274 Cornelis J. Van der Schyf, Werner J. Geldenhuys, and Moussa B. H. Youdim 18. INTERPRETING CLINICAL STUDIES OF PUTATIVE THERAPEUTICS FOR ALZHEIMER’S DISEASE: THE CASE OF STATINS AND NSAIDs . . . . . . . . . . . . . . . . . . 296 Benjamin Wolozin INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 |
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