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[资源] Pharmacological Mechanisms in Alzheimer's Therapeutics

Pharmacological Mechanisms in Alzheimer's Therapeutics
by Claudio Cuello
Springer
Oct. 31, 2007
ISBN: 0387978798

Contents
xi
FOREWORDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v
William H. Thies
Theodore L. Sourkes
PREFACE FROM THE EDITOR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
A. Claudio Cuello
LIST OF CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv
1. OVERVIEW OF THE ALZHEIMER’S DISEASE PATHOLOGY AND POTENTIAL THERAPEUTIC TARGETS . . . . . . . . . . . . . 1
A. Claudio Cuello
2. TRIAL DESIGNS AND OUTCOMES TO MONITOR NOVEL THERAPEUTICS IN ALZHEIMER’S DISEASE . . . . . . . . . . . . 28
Serge Gauthier
3. THE PHARMACOLOGICAL TREATMENT OF ALZHEIMER’S DISEASE WITH CHOLINESTERASE INHIBITORS AND MEMANTINE . . . . . . . . . . . . . . . . . . 36
Gordon Keith Wilcock
4. M1 MUSCARINIC AGONISTS: A COMPREHENSIVE
THERAPY AGAINST MAJOR HALLMARKS OF
ALZHEIMER’S DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
Abraham Fisher
5. CHOLINERGIC NEURODEGENERATION IN ALZHEIMER’S DISEASE: BASIS FOR NERVE GROWTH FACTOR THERAPY. . . . .
Ahmad Salehi, Alexander Kleshevnikov, and William C. Mobley
6. THE RATIONALE FOR GLUTAMATERGIC THERAPY IN ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Paul T. Francis
7. SECRETASES AS PHARMACOLOGICAL TARGETS IN ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Nigel M. Hooper and Emma R. L. C. Vardy
8. g-SECRETASE AS A TARGET FOR ALZHEIMER’S DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Michael S. Wolfe
9. THE RATIONALE FOR AN IMMUNOLOGICAL APPROACH TO ALZHEIMER’S THERAPEUTICS . . . . . . . . 141
Dave Morgan
10. NEUROINFLAMMATION, ALZHEIMER DISEASE, AND OTHER AGING DISORDERS . . . . . . . . . . . . . . . . . . . . . 149
Edith G. McGeer and Patrick L. McGeer
11. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) AND DERIVED Ab42-LOWERING MOLECULES FOR TREATMENT AND PREVENTION OF ALZHEIMER’S
DISEASE (AD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Sascha Weggen, Eva Czirr, Stefanie Leuchtenberger, and Jason Eriksen
12. THE POTENTIAL APPLICATION OF ANTIOXIDANT AGENTS IN ALZHEIMER DISEASE THERAPEUTICS. . . . . 194
Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, and George Perry
13. APOLIPOPROTEIN E: A POTENT GENE-BASED THERAPEUTIC TARGET FOR THE TREATMENT OF SPORADIC ALZHEIMER’S DISEASE. . . . . . . . . . . . . . . . 212
Judes Poirier
14. TAU PATHOLOGY AS A TARGET IN ALZHEIMER’S THERAPEUTICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Khalid Iqbal and Inge Grundke-Iqbal
15. DESIGN OF INHIBITORS OF AMYLOID-b MISFOLDING AND AGGREGATION FOR ALZHEIMER’S THERAPY . . . . 238
Lisbell D. Estrada, Cristian Lasagna, and Claudio Soto
16. POTENTIAL APPLICATIONS OF GLYCOSAMINOGLYCANRELATED COMPOUNDS IN ALZHEIMER’S DISEASE . . . . 255
Céline Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, and Barry D. Greenberg
17. MULTIFUNCTIONAL NEUROPROTECTIVE DRUGS
FOR THE TREATMENT OF ALZHEIMER’S DISEASE. . . . . 274
Cornelis J. Van der Schyf, Werner J. Geldenhuys,
and Moussa B. H. Youdim
18. INTERPRETING CLINICAL STUDIES OF PUTATIVE THERAPEUTICS FOR ALZHEIMER’S DISEASE: THE CASE OF STATINS AND NSAIDs . . . . . . . . . . . . . . . . . . 296
Benjamin Wolozin
INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309

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2016-05-08 14:17:39, 3.05 M