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Thiazole is a heterocyclic organic compound that has a fivemembered molecular ring structure with molecular formula C3H3NS. It possesses both an electron-donating group (-S-) and an electron-accepting group (C]N). It is a stable heterocyclic compound and has Bird IA value of 79. Thiazole is aromatic on the basis of delocalization of a lone pair of electrons from the sulphur atom completing the desirable 6 p electrons to fulfil Huckel's rule. The thiazole ring is present in many natural and synthetic products with a broad range of biological activities for example, thiazole containing vitamin B1 (thiamine) helps in the normal functioning of the nervous system by its role in the synthesis of acetylcholine [1]. Thiazole ring is highly reactive due to the presence of an acidic proton at C-2 and has emerged as an important synthon to generate variety of NCEs (New Chemical Entities). Diverse modifications of the thiazole ring at various positions led to a variety of novel compounds with wide spectrum of pharmacological activities such as antioxidant, antibacterial, antifungal, antitubercular, diuretic, anti-inflammatory and anticancer activities |
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