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【悬赏金币】回答本帖问题，作者yangyu198877将赠送您 10 个金币

yangyu198877

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虫号: 2813090
注册: 2013-11-19

[求助] 求大神看看审稿意见以及怎么修改问题，第一次投靠还望传授经验已有1人参与

Reviewers have now commented on your paper. You will see that they are advising that you revise your manuscript. If you are prepared to undertake the work required, I would be pleased to reconsider my decision.

For your guidance, reviewers' comments are appended below.

If you decide to revise the work, please submit a list of changes or a rebuttal against each point which is being raised when you submit the revised manuscript.

To submit a revision, go to https://jmmb.edmgr.com/ and log in as an Author. You will see a menu item call Submission Needing Revision. You will find your submission record there.

Yours sincerely

Eddie Yin-Kwee YK Ng, Ph.D.
Managing Editor
Journal of Mechanics in Medicine and Biology

Reviewer #1: CrossCheck/iThenticate Results (41%)
Duplicate Submission Check (25%)
The similarity index as above is far too high: it must be < 10%. You must revise and check the index until low index before any submission. if the revised index is still high, we will conclude and reject the paper.

This is an interesting report on the study of the effect of bracket of different shapes on the stress distribute of periodontal ligaments (PDL) under two type of orthodontic tooth movement (uncontrolled tipping and translation).

This work was carried out by computer simulation using FEA.

In any FE study, of great interest to researchers is the sensitivity of the stress to the parameter inputs. That is, how do the stress vary within a predetermined range of the respective input parameters. There are a few key arguments for wanting to know this. Firstly, FEA can be carried out fairly straight-forwardly without any practical constraints. PCs nowadays are powerful and can easily be employed to run/iterate the models to obtain a range of predictions. Secondly, knowing a range of values based on predictions from the FE model would help to understand the wider implications (clinical, biological) because the experimental values for the input parameters can never be known to certainty (subject to variabiliy due to age/degradation, tissue type, tissue physical size, tissue sample size, storage effects etc...) I understand that the study has more or less been concluded. I would be happy if the authors can, at least make useful in principle comments about this issue.
The authors are strongly encourage to refer to the following papers for supporting their arguments (in the results section or discussion section) and cite accordingly:

Sensitivity analysis of stress to input parameters:
Stress transfer in collagen fibrils reinforcing connective tissues: effects of collagen fibril slenderness and relative stiffness
Journal of theoretical biology, Volume 245 (2), 305-311, 2007

Influence of fibril taper on the function of collagen to reinforce extracellular matrix
Proceedings of the Royal Society of London B: Biological Sciences, Volume 272 p. 1575, 2005

Variability effects:
Ageing changes in the tensile properties of tendons: influence of collagen fibril volume fraction
Journal of biomechanical engineering, Volume 130 (2), 021011, 2008

Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture
Journal of Applied Physiology, Volume 113 (6), 878-888, 2012

Another great concern here that is of interest to current researchers is the actual stress uptake in the ligaments when loaded (i.e. arising from tooth movement). The authors could try to comment on other works that have applied non-invasive approach to determine stress in ligaments in the body, using e.g. MRI and imaging techniques. I would be happy if the authors can also, at the very least make useful in principle comments about this issue. The authors are strongly encourage to refer to the following paper for supporting their arguments (in the results section or discussion section) and cite accordingly

Magnetic Resonance Imaging of the Human Anterior Cruciate Ligament: Three-Dimensional Computer Reconstruction and Structural Analysis
Journal of Medical Imaging and Health Informatics, Volume 2 (4), 378-385, 2012

Finally, there are several typos in this manuscript and I strongly urged the authors to amend the paper by going over the paper carefully. E.g. in Table 1, the units for Elastic Modulus should be 'MPa' not 'MP'!

All said, this paper is interesting and deserve a further attempt at revision before further consideration.

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