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虫号: 4526980
注册: 2016-03-21
专业: 抗肿瘤药物药理

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The aim of the study was to prepare inhalable resveratrol by spray drying for the treatment of chronic
obstructive pulmonary disease (COPD). Resveratrol, with a spherical morphology and particle diameter
less than 5 mm, was successfully manufactured. Fine particle fraction (FPF) and mass median
aerodynamic diameter (MMAD) of spray-dried resveratrol was 39.9

1.1% and 3.7

0.1 mm, respectively,
when assessed with an Andersen cascade impactor (ACI) at 60 l/min. The cytotoxicity results of
resveratrol on Calu-3 revealed that the cells could tolerate high concentration of resveratrol (up to
160 mM). In addition, in transport experiments using Snapwells, it was observed that more than 80% of
the deposited dry powder was transported across the Calu-3 cells to the basal chamber within four hours.
The expression of interleukin-8 (IL-8) from Calu-3 induced with tumor necrosis factor alpha (TNF-a),
transforming growth factor beta (TGF-b1) and lipopolysaccharide (LPS) were significantly reduced after
treatment with spray-dried resveratrol. The antioxidant assay (radical scavenging activity and nitric
oxide production) showed spray-dried resveratrol to possess an equivalent antioxidant property as
compared to vitamin C. Results presented in this investigation suggested that resveratrol could
potentially be developed as a dry powder for inhalation for the treatment of inflammatory lung diseases
like COPD.

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