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The outer edges of the Lzr gene cluster were defined based on comparisons to the BE-54017 and cladoniamide gene clusters and a BLAST analysis of genes surrounding the core indolotryptoline biosynthesis genes (Fig. 3A). The biosynthesis of indolotryptolines is well-character- ized, making it possible to predict the function of most genes in the Lzr gene cluster (32). The four key stages of indolotryptoline biosynthesis involve dimerization of oxo-tryptophan to form a chromopyrrolic acid, oxidative aryl–aryl coupling to form an indolocarbazole, “flipping” of one of the indole rings to form an indolotryptoline, and tailoring to generate the final product. The Lzr gene cluster is predicted to contain seven transcriptional units controlled by three bidirectional (P1, P2, and P3) and one unidirectional (P4) promoter regions (Fig. 3 B, i). This cluster is conveniently organized such that successive activation of the three bidirectional promoter regions (P1, P2, and P3) is predicted to drive the expression of genes required to achieve the first, second, and third stages in indolotryptoline biosynthesis, respectively (Fig. 3C). |
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| 基于对BE-54017以及cladoniamide基因簇的比较，以及吲哚色氨酸周围基因生物合成的BLAST分析（图3A），我们定义了Lzr基因簇的范围。吲哚色氨酸的生物合成是人们所熟知的，这使得预测Lzr基因簇中的基团功能成为可能。吲哚色氨酸的四个关键合成步骤包括1.氧杂色氨酸形成吡咯酸，2. 氧化芳基-芳基偶联生成吲哚咔唑, 3. 吲哚环的骨架迁跃生成吲哚色氨酸琳，4. 形成终产物。Lzr基因簇含有七个转录单元，由三个双向启动区P1 P2 P3以及一个单向启动区P4控制 。这种有序的组织使得连续活化 三个双向启动区（P1 P2 P3）成为一种驱动力，分别实现吲哚色氨酸的三个阶段性合成 |
2楼2016-04-12 23:25:08