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Because known indolotryptolines are potent human cell line toxins, previously unknown compounds 5–7, as well as cladoniamide A (3) as a control, were tested for cytotoxicity against HCT-116 human colon carcinoma cancer cells. The IC 50 s observed for compounds 3 and 5–7 were 40.4 nM, 25.8 μM, 11.6 nM, and 8.4 nM, respectively (Fig. 3D). In this series of closely related natural products, lazarimide A (7) exhibits the most potent cytotoxicity against human cells. Activation of the Lzr gene cluster demonstrates the utility of our platform toward characterizing new biomedically relevant metabolites through the activation not only of silent but also of naturally dead biosynthetic gene clusters. |
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bxzc123: 金币+35, 翻译EPI+1 2016-03-29 19:25:16
bxzc123(RXMCDM代发): 金币+10 2016-04-09 19:41:51
bxzc123: 金币+35, 翻译EPI+1 2016-03-29 19:25:16
bxzc123(RXMCDM代发): 金币+10 2016-04-09 19:41:51
| 因为·已知indolotryptolines是人类细胞系的毒素，未知化合物5-7，以及cladoniamide A（3）作为控制来检测人类结肠癌癌细胞HCT-116的细胞毒性。IC50年代观察的化合物3和5-7是40.4纳米，25.8微米，11.6纳米和8.4纳米如（图3D）。这个系列与天然产品密切相关，lazarimide(7)展示了对人类细胞最强有力的细胞毒性。激活的Lzr基因簇演示了我们平台对描述新的生物医学相关代谢物的激活的效用，不仅仅是悄无声息也是生物合成基因簇的自然死亡。ps：几个医学专用次查不到意思，翻译的可能不精准 |
2楼2016-03-29 10:57:11
