24小时热门版块排行榜    

查看: 4356  |  回复: 7
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

小木屋菜鸟

新虫 (小有名气)

[求助] 请问乙醇、聚氧乙烯蓖麻油1:1处方,其增溶紫杉醇原理,两者都起什么作用? 已有2人参与

不懂,请教各位虫友,谢谢
回复此楼
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

huangyixia

铁杆木虫 (正式写手)

【答案】应助回帖

★ ★ ★ ★ ★
感谢参与,应助指数 +1
小木屋菜鸟(卓越_先锋代发): 金币+5, 谢谢回复 2016-03-24 10:27:19
引用回帖:
2楼: Originally posted by hj2186 at 2016-03-19 09:39:59
紫杉醇在乙醇中的溶解度本来就很高,完全没有必要用蓖麻油。如果是将乙醇、蓖麻油和紫杉醇溶于水中,那感觉蓖麻油就是表面活性剂喽,不过完全没必要这样做

2楼说的不对,聚氧乙烯蓖麻油和乙醇是taxol的配方

Paclitaxel is currently formulated in a vehicle composed of 1:1 blend of Cremophor EL
(polyethoxylated castor oil) and ethanol which is diluted with 5–20-fold in normal saline or dextrose solution (5%) for administration. This formulation is stable in unopened vials for 5 years at 4 °C. However, lots of problems employing this
vehicle have been reported.

聚氧乙烯蓖麻油会形成类似胶束的结构,包裹紫杉醇
能受天磨真好汉,不遭人嫉是庸才。
3楼2016-03-20 03:32:40
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 8 个回答

hj2186

新虫 (小有名气)

【答案】应助回帖

感谢参与,应助指数 +1
紫杉醇在乙醇中的溶解度本来就很高,完全没有必要用蓖麻油。如果是将乙醇、蓖麻油和紫杉醇溶于水中,那感觉蓖麻油就是表面活性剂喽,不过完全没必要这样做
2楼2016-03-19 22:39:59
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

小木屋菜鸟

新虫 (小有名气)

引用回帖:
3楼: Originally posted by huangyixia at 2016-03-20 03:32:40
2楼说的不对,聚氧乙烯蓖麻油和乙醇是taxol的配方

Paclitaxel is currently formulated in a vehicle composed of 1:1 blend of Cremophor EL
(polyethoxylated castor oil) and ethanol which is diluted wit ...

形成的胶束在用生理盐水稀释的过程,或者制成制剂后静注入血稀释过程,会不会由于低于CMC而胶束破坏,紫杉醇析出。

发自小木虫IOS客户端
4楼2016-03-20 09:52:48
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

huangyixia

铁杆木虫 (正式写手)

能受天磨真好汉,不遭人嫉是庸才。
5楼2016-03-20 09:53:18
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[公派出国] 售SCI一区T0P文章,我:8.O.55.1.O54,科目全,可伽急 +4 hKe7U1kad5Sg 2026-10-31 6/300 2026-11-02 06:20 by xzcv0Tehd8lQ
[硕博家园] 售SCI一区文章,我:8.O.55.1.O.54,科目齐全,可伽急 +4 hKe7U1kad5Sg 2026-10-31 9/450 2026-11-02 06:13 by xzcv0Tehd8lQ
[考博] 售SCI一区文章,我:8.O.55.1.O.54,科目齐全,可伽急 +4 xvJS1BYDxvBS 2026-10-31 5/250 2026-11-02 06:07 by xzcv0Tehd8lQ
[公派出国] 售SCI文章,我:8O5.5.1.O.54,科目齐全,可+急 +3 xvJS1BYDxvBS 2026-10-31 8/400 2026-11-02 06:07 by xzcv0Tehd8lQ
[硕博家园] 售SCI一区T0P文章,我:8.O55.1.O.54,科目全,可十急 +5 xvJS1BYDxvBS 2026-10-31 11/550 2026-11-02 06:00 by xzcv0Tehd8lQ
[博后之家] 售SCI一区文章,我:8O5.5.1.O5.4,科目全,可伽急 +5 1uaZt2kAZj2S 2026-10-31 9/450 2026-11-02 05:54 by xzcv0Tehd8lQ
[考研] 售SCI一区T0P文章,我:8.O.55.1.O.54,科目齐全,可+急 +4 1uaZt2kAZj2S 2026-10-30 21/1050 2026-11-02 05:41 by xzcv0Tehd8lQ
[论文投稿] 售SCI一区T0P文章,我:8O.55.1.O.5.4,科目齐全,可+急 +3 hKe7U1kad5Sg 2026-10-31 5/250 2026-11-02 03:39 by xzcv0Tehd8lQ
[考博] 售SCI一区T0P文章,我:8.O.55.1.O.5.4,科目全,可+急 +4 hKe7U1kad5Sg 2026-10-31 9/450 2026-11-02 03:26 by xzcv0Tehd8lQ
[基金申请] 售SCI一区T0P文章,我:8.O.55.1.O.54,科目齐全,可+急 +5 1uaZt2kAZj2S 2026-10-31 5/250 2026-11-01 21:45 by xzcv0Tehd8lQ
[考博] 售SCI-T0P文章,我:8O.5.5.1.O.54,科目齐全,可+急 +5 1uaZt2kAZj2S 2026-10-31 7/350 2026-11-01 21:45 by xzcv0Tehd8lQ
[公派出国] 售SCI-T0P文章,我:8O.5.5.1.O.54,科目齐全,可+急 +4 1uaZt2kAZj2S 2026-10-30 8/400 2026-11-01 21:35 by xzcv0Tehd8lQ
[教师之家] 售SCI-T0P文章,我:8O.5.5.1.O.54,科目齐全,可+急 +6 X5bHxOULxFqb 2026-10-30 16/800 2026-11-01 21:19 by xzcv0Tehd8lQ
[论文投稿] 售SCI一区T0P文章,我:8.O.55.1.O54,科目全,可伽急 +3 hKe7U1kad5Sg 2026-10-31 5/250 2026-11-01 20:03 by xzcv0Tehd8lQ
[考博] 售SCI一区T0P文章,我:8.O.55.1.O.5.4,科目全,可+急 +5 X5bHxOULxFqb 2026-10-30 22/1100 2026-11-01 16:35 by BCdvBAEpt3zm
[考研] 售SCI一区T0P文章,我:8.O.55.1.O.5.4,科目全,可+急 +3 xvJS1BYDxvBS 2026-10-31 5/250 2026-11-01 12:51 by BCdvBAEpt3zm
[公派出国] 售SCI文章,我:8O5.5.1.O.54,科目齐全,可+急 +4 1uaZt2kAZj2S 2026-10-31 7/350 2026-11-01 12:40 by BCdvBAEpt3zm
[硕博家园] 售SCI一区T0P文章,我:8.O.55.1.O.5.4,科目全,可+急 +4 1uaZt2kAZj2S 2026-10-30 17/850 2026-11-01 12:24 by BCdvBAEpt3zm
[考研] 售SCI文章,我:8O.5.5.1O.54,科目全,可十急 +3 1uaZt2kAZj2S 2026-10-30 16/800 2026-11-01 12:14 by BCdvBAEpt3zm
[论文投稿] 售一区SCI文章T0P,我:8O.551.O54,科目全,可十急 +3 1uaZt2kAZj2S 2026-10-31 8/400 2026-11-01 03:59 by YXM1FDCSE8Bn
信息提示
请填处理意见