±±¾©Ê¯ÓÍ»¯¹¤Ñ§Ôº2026ÄêÑо¿ÉúÕÐÉú½ÓÊÕµ÷¼Á¹«¸æ
²é¿´: 554  |  »Ø¸´: 1

²¤ÂÜÃÛ

ľ³æ (³õÈëÎÄ̳)

[ÇóÖú] ¼±Çó·­Òë

µÄÈ·£¬µ±Ñ¹Á¦ÉÏÉýµ½18MPaʱ£¬Ò©ÎïÁ£¾¶»á˲¼äµÄϽµ10±¶¡£¶Ô´Ë£¬ÎÒÃÇ»¹¶îÍâ¶à½øÐÐÁ˼¸´ÎÖØ¸´ÊÔÑé½øÐÐÑéÖ¤¡£Ôì³ÉÕâÖÖÏÖÏóµÄÔ­Òò¿ÉÄÜÓÐÏÂÃæÁ½ÖÖÒòËØ£¬Ê×Ïȵ±Ñ¹Á¦¸ßÓÚ18MPaʱ£¬¾§ÐͳöÏÖÁËת±ä£¬ÓÉÕë×´¾§Ìå±äΪ±¡Æ¬×´¡£¾ÝÎÄÏ××ܽᣬÒÔÕë×´¾§Ìå½á¾§µÄ¾§ÌåÁ£¾¶ÆÕ±é±È½Ï´ó£»Æä´Î£¬µ±Éí¸ßѹÁ¦Ê±£¬¹ý±¥ºÍ¶ÈÔö¼Ó£¬Ò©Îï³ÉºËËÙÂÊÔö¼Ó¡£¶ÔÓÚÒÀÍв´ÜÕÒ©Îï¾§ÌåÀ´Ëµ£¬µ±Ñ¹Á¦Éý¸ß´ïµ½18MPaʱ£¬»á³öÏÖ¾§Ìå³ÉºËËÙÂÊ´óÓÚ¾§ÌåÉú³¤ËٶȵÄÁÙ½çµã¡£Òò´Ë£¬»á³öÏÖÕâÖÖÏÖÏó¡£

» ²ÂÄãϲ»¶

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

Î人һÐÄÒ»Òë

¾èÖú¹ó±ö (ÖøÃûдÊÖ)


¡¾´ð°¸¡¿Ó¦Öú»ØÌû

É̼ÒÒѾ­Ö÷¶¯ÉùÃ÷´Ë»ØÌû¿ÉÄܺ¬ÓÐÐû´«ÄÚÈÝ
¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ...
²¤ÂÜÃÛ: ½ð±Ò+200, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-03-04 16:30:08
µÄÈ·£¬µ±Ñ¹Á¦ÉÏÉýµ½ 18MPaʱ£¬Ò©ÎïÁ£¾¶ »á˲¼äµÄ Ͻµ10±¶¡£¶Ô´Ë£¬ÎÒÃÇ »¹¶îÍâ ¶à½øÐÐÁË ¼¸´ÎÖØ¸´ÊÔÑé ÐÐÑéÖ¤¡£Ôì³ÉÕâÖÖÏÖÏóµÄ Ô­Òò ¿ÉÄÜÓÐÏÂ ÃæÁ½ÖÖÒòËØ£¬Ê×ÏÈ µ±Ñ¹Á¦¸ßÓÚ 18MPaʱ£¬¾§ÐÍ ³öÏÖÁË ×ª±ä£¬ÓÉ Õë×´¾§Ìå ±äΪ ±¡Æ¬×´¡£¾ÝÎÄÏ××ܽᣬÒÔ Õë×´¾§Ìå ½á¾§µÄ ¾§ÌåÁ£¾¶ ÆÕ±é ±È½Ï´ó£»Æä´Î£¬µ± Éí¸ßѹÁ¦Ê±£¬¹ý±¥ºÍ Ôö¼Ó£¬Ò©Îï ³ÉºËËÙÂÊ Ôö¼Ó¡£¶ÔÓÚ ÒÀÍв´ÜÕ Ò©Îï¾§Ìå À´Ëµ£¬µ±Ñ¹Á¦Éý¸ß´ïµ½ 18MPaʱ£¬»á³öÏÖ ¾§Ìå³ÉºËËÙÂÊ ´óÓÚ ¾§ÌåÉú³¤ËÙ¶È µÄÁÙ½çµã¡£Òò´Ë£¬»á³ö ÏÖÕâÖÖÏÖÏó¡£
Indeed, when pressure reaches to 18MPa, the particle size of drug will be reduced by 10 times instantaneously. For this situation, we performed additional several repeated tests for verification. The cause for such situation may be due to following two factors. Firstly when pressure is higher than 18MPa, crystal form will be transformed from needle shaped crystal into thin plate shaped crystal. According to literature summary, we can know that the particle size of crystal, which is in form of needle shape during crystallization, is generally larger; Secondly, an increased pressure will lead to an increased degree of supersaturation as well as increased nucleation rate of drug. Regarding Etoposide drug crystals, when pressure reaches 18MPa, it will pass the critical point where the crystal nucleation rate is over crystal growth rate. Therefore, such situation will be caused.


ÔÚ¶àÆª ³¬ÁÙ½çÁ÷Ìå½á¾§¼¼Êõ ÎÄÏ×±¨µÀÖУ¬Í¬Ñù³öÏÖÁË Í¨¹ý¸Ä±ä ÊÔÑé²ÎÊý£¬¶øµÃµ½ÁË ²»Í¬¾§ÐÍ µÄÏà¹Ø±¨µÀ¡£×îºó£¬ÎÒÃÇÔÚ ÎÄÕÂÖÐ Ò²²¹³äÁË ¶ÔÕâÒ»ÏÖÏóµÄ ½âÊÍ¡£
In several documents on supercritical fluid crystallization technology, we can also see several reports on obtaining different crystal structure through changing experimental parameters. At last, we also added the explanation for this phenomenon.
2Â¥2016-03-04 16:29:14
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ ²¤ÂÜÃÛ µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ²ÄÁÏ¿¼ÑÐÇóµ÷¼Á×Ü·Ö280 +3 mkjlz1 2026-04-06 3/150 2026-04-06 14:40 by zhen¡«
[¿¼ÑÐ] ²ÄÁϹ¤³Ì310ר˶µ÷¼Á +14 ÀÌÀÌÎÒ¡­. 2026-04-04 15/750 2026-04-06 14:18 by lqwchd
[¿¼ÑÐ] Çóµ÷¼Á +8 ÕÅzic 2026-04-05 9/450 2026-04-06 13:03 by Öí»á·É
[¿¼ÑÐ] ÉúÎïѧѧ˶Çóµ÷¼Á£º351·ÖÒ»Ö¾Ô¸ÄϾ©Ê¦·¶´óѧÉúÎïѧרҵ +4 ¡­¡«¡¢Íõ¡­¡« 2026-04-06 5/250 2026-04-06 10:45 by ´óÁ¦Ë®ÊÖÁ¦´óÎÞÇ
[¿¼ÑÐ] ¿¼Ñе÷¼Á +5 ÃÀÀöµÄyouth_ 2026-04-04 6/300 2026-04-06 06:57 by houyaoxu
[¿¼ÑÐ] 081200-11408-276ѧ˶Çóµ÷¼Á +4 ´Þwj 2026-04-05 4/200 2026-04-05 20:29 by à£à£à£0119
[¿¼ÑÐ] 282Çóµ÷¼Á +7 aaa³µÁ¾ 2026-04-02 11/550 2026-04-05 17:24 by yulian1987
[¿¼²©] É격 +7 IQwQl 2026-04-04 7/350 2026-04-04 23:32 by mumin1990
[¿¼ÑÐ] ²ÄÁϵ÷¼Á +11 Ò»ÑùYWY 2026-04-02 13/650 2026-04-04 23:10 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] µ÷¼Á +11 JLLLLLLLLLL 2026-04-03 11/550 2026-04-04 22:21 by hemengdong
[¿¼ÑÐ] 0854Çóµ÷¼Á +4 assdll 2026-04-03 4/200 2026-04-04 22:17 by hemengdong
[¿¼ÑÐ] 309Çóµ÷¼Á +14 ´ô¹½²»ÊÇ´÷·ò 2026-04-02 14/700 2026-04-03 09:42 by À¶ÔÆË¼Óê
[¿¼ÑÐ] 0856²ÄÁÏÓ뻯¹¤µ÷¼Á£¬339 +14 10213207 2026-03-31 14/700 2026-04-02 21:01 by 1104338198
[¿¼ÑÐ] ²ÄÁÏרҵÇóµ÷¼Á +10 ÔÂÔÂÄñľ 2026-04-01 10/500 2026-04-02 12:57 by wxiongid
[¿¼ÑÐ] 314Çóµ÷¼Á +11 1xiaojun23 2026-03-31 12/600 2026-04-02 12:31 by 1xiaojun23
[¿¼ÑÐ] Ò»Ö¾Ô¸±±½»´ó²ÄÁϹ¤³Ì×Ü·Ö358 +8 cs0106 2026-04-01 9/450 2026-04-02 10:36 by ²»³Ôô~µÄ؈
[¿¼ÑÐ] 349Çóµ÷¼Á +6 ³ÔµÄ²»ÉÙ 2026-04-01 6/300 2026-04-01 17:55 by JYD2011
[¿¼ÑÐ] 085600£¬321·ÖÇóµ÷¼Á +13 ´ó²öС×Ó 2026-03-31 13/650 2026-04-01 12:35 by chemdavid
[¿¼ÑÐ] 262Çóµ÷¼Á +9 ÀøÖ¾Ò»¶¨·¢ÎÄÕ 2026-03-31 10/500 2026-04-01 12:22 by sunshine0013
[¿¼ÑÐ] 267Çóµ÷¼Á +13 uiybh 2026-03-31 13/650 2026-04-01 10:25 by ̽123
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û