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yyc12596新虫 (著名写手)
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SCI二审大修 这个周末要改出来了 已有28人参与
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SCI二审大修，这个周末必须改出来。下周一去找导师审核。 期盼着SCI能中。 但是想到修改，只觉得愁得喘不动气。 |
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yyc12596
新虫 (著名写手)
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文献Munc18b/STXBP2 is required for platelet secretion 内容In mammals, there are 7 SM proteins, and each has been assigned to specific types of membrane-trafficking events: Munc18a, Munc18b, and Munc18c for exocytosis. 这个内容说明Munc18b和Munc18c都在胞吐中起作用。 内容 Munc18b (also called STXBP2 or Munc18-2) is broadly expressed and has been shown to interact with syntaxin-1A, -1B, -2, and -3.12 Munc18b plays a role in exocytosis from mast cells,18 neutrophils,19 and natural killer (NK) cells.20,21 Munc18c (also called STXBP3, PSP, or Munc18-3) is ubiquitously expressed22,23 and can interact with both syntaxin-2 and -4. The interaction between Munc18c and syntaxin-4 is important for insulin release from adipose tissue and muscle cells and is important in endothelial cell activation. 这个内容说明Munc18b在NK细胞的胞吐中起作用。Munc18-3在脂肪和肌肉细胞中起作用。 内容In human and mouse platelets, 3 Munc18 isoforms are present: Munc18a, Munc18b, and Munc18c. 人和鼠血小板中，Munc18b和Munc18c都存在。 |
32楼2016-02-29 13:37:23
yyc12596
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Major comments: *(1) The presentation of the genetic results should be improved further. The nomenclature mutation, SNP, single heterozygous used by the authors is very confusing. Please rename the results section are "genetic results" and in table 1 use the term "Summary of genetic findings". It is not immediately clear from table 1 which one are real mutations and which one are polymorphisms or variants of unknown significance. Maybe the authors can reorganize the table to clarify that. |
3楼2016-02-27 17:59:05
yyc12596
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4楼2016-02-27 18:01:10
yyc12596
新虫 (著名写手)
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5楼2016-02-27 18:06:08