传统的ADC药物通常受限于较低的药物-抗体比（DAR）以及因疏水性药物偶联导致的聚集问题。我们的策略是利用精密设计的聚合物前药（PolymerProdrugs）作为载体，偶联至特异性抗体上。通过这种...

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NikitaM.Chernov,RomanP.Kustin,YuliaV.Pypa,SergejO.Anisimov,Dar\'yaV.Spiridonova,RomanV.Shutov,IgorP.YakovlevTandemRing-Opening/DoubleRing-ClosingSynthesisof1,2,4-Triazolo[1,5-a...

By:Dar\'in,Dmitry;etalTheChan-Evans-LamN-Arylationof2-ImidazolinesJournalofOrganicChemistry2016(2016),81(24),12514-12519

Dar’in,DmitryVThesynthesisof1-oxa-9-azaspiro[5.5]undecanederivativesandoptimizationofantituberculosisactivitythereofChemistryofHeterocyclicCompounds,2024,vol.60,#5-6,p.245-...

JonathanAlexisCórdovaa1,JuanCruzPalermob1,DaríoA.Estrinab,SaraE.Barib,LucianaCapeceabBindingmechanismofdisulfidespeciestoferrichemeproteins:...October2023,112313Volume247,...

Dar,TawseefAhmadUprety,BhawnaSankar,MuniappanMaurya,MannarR.Robustandelectrondeficientoxidovanadium(IV)...

求助谢谢BernhardLudvik1,FrancescoGiorgino2,EstebanJódar3,JuanPFrias4,LauraFernándezLandó5,KatelynBrown5,RossBray5,?ngelRodríguez6Once-weeklytirzepatideversusonce-...

andTheirFoodApplicationsAppleAcademicPress2025...refId=7aee4fa8-08a4-4b15-a82a-06b29830f49b358PDF且可复制9781003518907

Dar,MS(Dar,MohammadSultan);Verma,S(Verma,Saurabh)DevelopmentoftubulinpolymerizationinhibitorsasanticanceragentsEXPERTOPINIONONTHERAPEUTICPATENTS2023Volume33;Issue11;Page797-...

Dar,MAImplicationsofthePoreSizeofGraphiticCarbonNitrideMonolayersontheSelectivityofDual-BoronAtomCatalystsfortheReductionofN2toUreaandAmmonia:...pp.13672-1367910.1021/acs....

备注-求助的是原版pdf格式SwatiKapoor,GurkiratKaur,B.N.Dar,SavitaSharmaEmergingTechniquesforFoodProcessingandPreservationCRCPress2023https://doi.org/10.1201/9781003217138296PDF且...

任务2也初见成效，在高分子骨架上偶联上了小分子，平均DAR为0.8。不过在之后的实验汇报中，领导增加难度，要求高分子骨架上DAR值要达到10以上；然后在高分子骨架端口设计linker，可以进一步...

这是一个michael加成反应，反应本身是好做的，而且工作环境比较干净、危化品毒害小，工作的主要问题有两个大的方面：1.ADC的品质控制比较严格，比如载药量DAR要求是4，那做出来的ADC必须是...

工业C_T：请不要应助不是原版PDF格式的...ArashdeepSingh,SavitaSharma,B.N.Dar,FatmaBoukidPigmentedGrainsNutritionalProperties,BioactivePotential,andFoodApplicationAcademicPress2024...

求助原版pdf文件，不要其它格式SajidAli,ShabirAhmadMir,B.N.Dar,ShaghefEjazSustainablePostharvestTechnologiesforFruitsandVegetablesCRC2024...refId=3d0268c9-d7a9-4b29-9bd8-8a4ba5ed...

ADC的成功取决于这些关键组分的选择以及将linker连接到抗体的偶联方法，这决定了药物抗体比(DAR)。抗体-毒素偶联物或免疫毒素。免疫毒素有两种成分，一种是靶向抗体或抗体的Fv，另一种是...

L....Volume40,Issue6September2021Pages900-913https://doi.org/10.1111/dar.13281JohnWiley+Blackwell需要PDF

3.2药物抗体偶联比（DAR）对于赖氨酸链接的抗体偶联药物，采用C4色谱柱及联用的质谱对去糖基化样品进行分析，根据偶联不同数目药物分子的质量数增加判断偶联数目。对于质谱测定的结果，不仅...

ManiSengoden,GulzarA.Bhat,RyanJ.Rutledge,ShowkatRashid,AijazA.Dar,andDonaldJ.DarensbourgMicellarcatalysisolymerboundpalladiumcatalystforcarbon-...

Dar,BashirAhmad;Isaev,AbdulgalimB.;Lone,Yaqoob;Banday,MudasirRashidFlavonoids:AReservoirofDrugsfromNatureMiniReviewsinMedicinalChemistry,Volume23,Number7,2023,pp.772-786(15)...

NikolayV.Shcherbakov,DmitryV.Dar’in,VadimYu.Kukushkin,andAlexeyYu.Dubovtsev*Gold-CatalyzedNitreneTransferfromBenzofuroxanstoN-Allylynamides:Synthesisof3-Azabicyclo[3.1.0]...

YanChenDrug-to-antibodyratio(DAR)byUV/VisspectroscopyAntibody-DrugConjugates2013267-273DOI:10.1007/978-1-62703-541-5_16...

JunOuyangDrug-to-AntibodyRatio(DAR)andDrugLoadDistributionbyHydrophobicInteractionChromatographyandReversedPhaseHigh-PerformanceLiquidChromatographyAntibody-DrugConjugates...