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xiaoluweiwei

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[交流] PhD position at the ZMBH der Universität Heidelberg

Title: Interphase nuclear pore complex biogenesis
Summary: The nuclear pore complex (NPC) is a large cylindrical structure with multiple copies of over 30 different proteins named nucleoporins. The NPC is embedded in the nuclear envelope (NE) at fusion sites of the inner and outer nuclear membrane where it facilitates nuclear-cytoplasmic transport of RNA and proteins. NPCs assemble in the intact nuclear envelope (interphase human cells or yeast cells with a closed mitosis) by an inside-out mechanism. Nucleoporins become deposited from within the nucleus to the inner nuclear membrane, deform this membrane and eventually, the inner and outer nuclear membranes fuse. Recently, we have identified that Brr6 and Brl1, two conserved integral membrane proteins of the NE, play a role in NE fusion during NPC biogenesis. Furthermore, the yeast microtubule organizing center, the spindle pole body (SPB), probably needs an NPC for its insertion into the NE. However, it is not understood if this NPC is delivering insertion factors or if the SPB uses the NPC to actively insert through the pore of the NPC into the NE. This NPC might be sacrificed during the SPB insertion process or could be released from the SPB sideways into the NE.

Applications should be sent via Email to Prof. Elmar Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de) and contain the following documents (in English): CV, motivation letter, two references.

Description:
https://hbigs.system08.de/intern ... 0000100007701410000

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