| 查看: 415 | 回复: 1 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
[求助]
求翻译，谢谢，站内信求大神帮忙
|
|||
|
Microbial hydroxylation of steroids provides a useful mild synthetic method for obtaining access to rare steroids [71]. The cyclopropane ring of the 3 a -5-cyclosteroids is sensitive to a variety of reagents limiting many chemical reactions. The fission of a cyclopropane ring in the presence of an adjacent radical has provided a probe for enzyme mechanism [72]. Incubation of 6b-hy-droxy-3 a , 5-cycloandrostan-17-one (145) with C. aphidicola [73]for 8 days yielded six metabolites that were identified as14 a -hydroxy-3 a ,5-cycloandrostane-6, 17-dione (145), 3b, 14 a -dihydroxyandrost-5-en-17-one (146), 6b, 14 a -dihydroxy-3 a , 5-cycloandrostan-17-one (147), 3b, 7 a -dihydroxyandrost-5-en-17-one (148), 3b, 7b-dihydroxyandrost-5-en-17-one (149) and 3b, 5 a , 6b-trihydroxyandrostan-17-one (150) (Scheme 23). Simi-larly, incubation of 3 a , 5-cycloandrostane-6, 17-dione (151) with C. aphidicola [73] yielded 145 and 2 a -hydroxy-3 a , 5-cycloandros-tane-6, 17-dione (152), while 3 a , 5-cycloandrost-6-en-17-one (153) afforded 148 and 6b, 7 a -dihydroxy-3 a , 5-cycloandrostane-17-one (154) with the same fungus [73]. These microbial conversions are shown in Scheme 23. a为α， b 为β |
回复此楼» 猜你喜欢
垃圾破二本职称评审标准
已经有19人回复
-
职称评审没过，求安慰
已经有53人回复
-
毕业后当辅导员了，天天各种学生超烦
已经有5人回复
-
26申博自荐
已经有3人回复
-
A期刊撤稿
已经有4人回复
jiangguofeng
金虫 (著名写手)
- 翻译EPI: 248
- 应助: 41 (小学生)
- 金币: 25692.4
- 红花: 25
- 帖子: 2054
- 在线: 566.7小时
- 虫号: 72410
- 注册: 2005-06-04
- 专业: 合成药物化学
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
bxzc123: 金币+75, 翻译EPI+1, ★★★很有帮助 2015-04-27 19:08:00
bxzc123: 金币+75, 翻译EPI+1, ★★★很有帮助 2015-04-27 19:08:00
| 甾族化合物的微生物羟基化作用为获得稀少的甾族化合物提供了一种有用的温和合成方法。3 a - 5 -环甾族化合物的环丙烷环对各种限制许多化学反应的试剂敏感。在一个相邻基团存在下环丙烷环的开环为酶作用机理提供了一个探针[72]。 用头孢霉属真菌C. aphidicola [73]培育6b-羟基-3a, 5-环雄甾-17-酮(145)８天得到六种代谢产物，分别鉴别为14 a -羟基-3 a，5-环雄甾-６、17-二酮（145）、3b, 14 a-二羟基雄甾-５-烯-17-酮( 146)、6b, 14 a-二羟基-3 a,５-环雄甾-17-(147)、 3b, 7 a -二羟基雄甾-５-烯-17-酮( 148)、3b,7b-二羟基雄甾-5-烯-17-酮( 149)和3b, 5 a, 6b-三羟基雄甾-17-酮(150)图23）。Simi-larly,用头孢霉属真菌C. aphidicola [73]培育3 a,5-环雄甾- 6,17-二酮(151)得到145和2 a -羟基- 3 a, 5-环雄甾-6, 17-二酮(152),而用同样的真菌[73]由3 a, 5 -环雄甾-6-烯-17-酮(153)得到了148和6b,7a-二羟基-3 a,5-环雄甾-17-酮(154)。这种微生物引起的转化作用具体请见图23。 |
2楼2015-04-27 19:05:13