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[资源] 剑桥2012年英文原版Mechanics of the Cell 2nd ed

作者：David Boal
Simon Fraser University
Canada
Exploring the mechanical features of biological cells, including their architecture
and stability, this textbook is a pedagogical introduction to the
interdisciplinary fields of cell mechanics and soft matter physics from both
experimental and theoretical perspectives.
This second edition has been greatly updated and expanded, with new
chapters on complex filaments, the cell division cycle, the mechanisms
of control and organization in the cell, and fluctuation phenomena. The
textbook is now in full color which enhances the diagrams and allows the
inclusion of new microscopy images.
With more than 300 end-of-chapter exercises exploring further applications,
this textbook is ideal for advanced undergraduate and graduate
students in physics and biomedical engineering. A website hosted by the
author contains extra support material, diagrams and lecture notes, and is
available at www.cambridge.org/Boal.
David Boal is Professor Emeritus in the Department of Physics at Simon
Fraser University, Canada. He has been working in the field of biophysics
for the past 20 years, and he now studies the mechanical issues in the origin
of life.
Preface page ix
List of symbols xi
1 Introduction to the cell 1
1.1 Designs for a cell 4
1.2 Cell shapes, sizes and structures 9
1.3 Biomaterials: soft strings and sheets 15
1.4 Forces inside and outside the cell 19
Summary 23
2 Soft materials and fluids 25
2.1 Fluctuations at the cellular scale 25
2.2 Movement in a viscous fluid 30
2.3 Random walks 37
2.4 Diffusion 41
2.5 Fluctuations and correlations 47
Summary 51
Problems 54
Part I Rods and ropes 61
3 Polymers 63
3.1 Polymers and simple biofilaments 63
3.2 Mathematical description of flexible rods 68
3.3 Sizes of polymer chains 75
3.4 Entropic elasticity 80
3.5 Buckling 85
3.6 Measurements of bending resistance 90
Summary 97
Problems 98
4 Complex filaments 105
4.1 The structure of complex filaments 106
4.2 Torsion, twist and writhe 110
4.3 Measurements of torsional rigidity 118
4.4 Stretching of folded polymers 123
Contents
vi Contents
4.5 Protein and RNA folding – concepts 127
4.6 Models for polymer folding 133
Summary 142
Problems 144
5 Two-dimensional networks 151
5.1 Soft networks in the cell 151
5.2 Elasticity in two dimensions 156
5.3 Isotropic networks 163
5.4 Networks with low coordination number 168
5.5 Membrane-associated networks 173
Summary 180
Problems 182
6 Three-dimensional networks 194
6.1 Networks of biological rods and ropes 194
6.2 Elasticity in three dimensions 199
6.3 Entropic networks 205
6.4 Network percolation and failure 209
6.5 Semiflexible polymer solutions 214
6.6 Rheology of cytoskeletal components 221
Summary 229
Problems 230
Part II Membranes 241
7 Biomembranes 243
7.1 Membranes, walls and lamina 243
7.2 Self-assembly of amphiphiles 250
7.3 Bilayer compression resistance 257
7.4 Bilayer bending resistance 263
7.5 Edge energy 268
7.6 Cell walls and sheaths 274
Summary 280
Problems 282
8 Membrane undulations 292
8.1 Thermal fluctuations in membrane shape 292
8.2 Mathematics of curvature 294
8.3 Membrane bending and persistence length 299
8.4 Scaling of polymers and membranes 305
8.5 Measurement of membrane undulations 313
Summary 319
Problems 321
vii Contents
9 Intermembrane and electrostatic forces 326
9.1 Interactions between membranes 326
9.2 Charged plate in an electrolyte 330
9.3 van der Waals and electrostatic interactions 337
9.4 Entropic repulsion of sheets and polymers 346
9.5 Adhesion 352
Summary 361
Problems 363
Part III The whole cell 371
10 The simplest cells 373
10.1 Cell shapes 373
10.2 Energetics of thin shells 375
10.3 Pure bilayer systems 381
10.4 Vesicles and red blood cells 390
10.5 Bacteria 397
Summary 403
Problems 405
11 Dynamic filaments 412
11.1 Movement in the cell 412
11.2 Polymerization of actin and tubulin 418
11.3 Molecular motors 428
11.4 Forces from filaments 435
11.5 Cell propulsion 439
Summary 446
Problems 448
12 Growth and division 454
12.1 Overview of the division cycle 455
12.2 Growth of rods and cocci 462
12.3 Asymmetry and asynchrony in cell division 469
12.4 Transcription and replication 476
12.5 Forces arising in cell division 485
Summary 490
Problems 492
13 Signals and switches 496
13.1 Axons and the action potential 496
13.2 Signal propagation in nerves 503
13.3 Rate equations: switches and stability 509
13.4 Molecular basis of regulation 513
viii Contents
Summary 520
Problems 523
Appendix A Animal cells and tissues 525
Appendix B The cell’s molecular building blocks 531
Appendix C Elementary statistical mechanics 539
Appendix D Elasticity 546
Glossary 554
References 565
Index 603

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2015-01-27 12:15:18, 17.69 M