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[资源] Science Review：癌症药物-用于成像和治疗

Cancer Nanomedicine- From Drug Delivery to Imaging

Nanotechnology-based chemotherapeutics and imaging agents represent a new era of “cancer nanomedicine”
working to deliver versatile payloads with favorable pharmacokinetics and capitalize on molecular and cellular
targeting for enhanced specificity, efficacy, and safety. Despite the versatility of many nanomedicine-based
platforms, translating new drug or imaging agents to the clinic is costly and often hampered by regulatory
hurdles. Therefore, translating cancer nanomedicine may largely be application-defined, where materials are
adapted only toward specific indications where their properties confer unique advantages. This strategy may
also realize therapies that can optimize clinical impact through combinatorial nanomedicine. In this review, we
discuss how particular materials lend themselves to specific applications, the progress to date in clinical
translation of nanomedicine, and promising approaches that may catalyze clinical acceptance of nano.

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2014-10-12 07:38:13, 1.72 M