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激光晶体

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[资源] Nature Comm.新近文献: 一种基于介孔纳米的医学诊断纳米药物

A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show
great promise towards personalized nanomedicine. However, attaining consistently high
performance of these functions in vivo in one single nanoconstruct remains extremely
challenging. Here we demonstrate the use of one single polymer to develop a smart
‘all-in-one’ nanoporphyrin platform that conveniently integrates a broad range of clinically
relevant functions. Nanoporphyrins can be used as ampliﬁable multimodality nanoprobes for
near-infrared ﬂuorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron
emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the
imaging sensitivity for tumour detection through background suppression in blood, as well as
preferential accumulation and signal ampliﬁcation in tumours. Nanoporphyrins also function
as multiphase nanotransducers that can efﬁciently convert light to heat inside tumours for
photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT).
Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted
delivery of drugs or therapeutic radio-metals into tumours.

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附件 1 : A_smart_and_versatile_theranostic_nanomedicine_platform_based_on_nanoporphyrin.pdf

2014-10-12 07:23:43, 2.59 M