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Recent Progress in the Synthesis of Bifunctional Diethylenetriaminepentaacetic Acid Derivatives Ligand for Magnetic Resonance Imaging Contrast Agent
×÷Õß:Wan, FX (Wan, Fuxian)[ 1 ] ; Yu, KC (Yu, Kaichao)[ 2 ]
CHINESE JOURNAL OF ORGANIC CHEMISTRY
¾í: 34 ÆÚ: 4 Ò³: 613-629
DOI: 10.6023/cjoc201310052
³ö°æÄê: APR 2014
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Diethylenetriaminepentaacetic acid (DTPA) and its derivatives have been used in chemistry, biology, medicine and many other fields due to their coordination properties, especially, used as magnetic resonance imaging (MRI) contrast agent. Bifunctional-DTPA ligand can be easily and readily linked to various biomolecules. It is of primary importance for the development high relaxation efficiency and/or targeted MRI contrast agents, but the synthesis of bifunctional-DTPA ligand is rather difficult. In this review, various synthetic methods for synthesizing these compounds are summarized.
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×÷Õ߹ؼü´Ê:magnetic resonance imaging; DTPA; gadolinium-complexes; bifunctional chelator; synthesis
KeyWords Plus:CHAIN ALKYL ESTERS; NEPHROGENIC SYSTEMIC FIBROSIS; L-LYSINE; IN-VIVO; GADOLINIUM COMPLEXES; PHYSICOCHEMICAL CHARACTERIZATION; RELAXATION ENHANCEMENT; LANTHANIDE COMPLEXES; GD(III) COMPLEXES; DTPA DERIVATIVES
×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Wan, FX (ͨѶ×÷Õß)
Shan Dong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China.
µØÖ·:
[ 1 ] Shan Dong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China
[ 2 ] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China
µç×ÓÓʼþµØÖ·:yukc@163.com
»ù½ð×ÊÖúÖÂл
»ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ
National Natural Science Foundation of China
20675033
Science and Technology Development of Shandong Province
2013CEX2019
²é¿´»ù½ð×ÊÖúÐÅÏ¢
³ö°æÉÌ
SCIENCE PRESS, 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Chemistry
Web of Science Àà±ð:Chemistry, Organic
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍ:Review
ÓïÖÖ:Chinese
Èë²ØºÅ: WOS:000336107900001
ISSN: 0253-2786
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Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®
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IDS ºÅ: AH4OM
Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 87
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
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