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Ph. Eur. 5.5 (Oxytetracycline Dihydrate). A substance produced by the growth of certain strains of Streptomyces rimosus or obtained by any other means. A yellow, crystalline powder. Very slightly soluble in water; dissolves in dilute acid and alkaline solutions. A 1% suspension in water has a pH of 4.5 to 7.5. Store in airtight containers. Protect from light. USP 29 (Oxytetracycline). A pale yellow to tan, odourless crystalline powder, that darkens on exposure to strong sunlight. Soluble 1 in 4150 of water, 1 in 66 of dehydrated alcohol, and 1 in 6250 of ether; sparingly soluble in alcohol; practically insoluble in chloroform; freely soluble in 3N hydrochloric acid and in alkaline solutions. pH of a 1% suspension in water is between 4.5 and 7.0. It loses potency in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. Store in airtight containers. Protect from light. ÍÁÃ¹ËØ,USP: dz»ÆÉ«ÖÁרɫ£¬ÎÞζ½á¾§·ÛÄ©£¬Ç¿ÈÕ¹âϱäºÚ¡£Ò»·ÝÈÜÓÚ4150·ÝË®£¬66·ÝÎÞË®ÒÒ´¼£¬6250·ÝÒÒÃÑ£»ÄÑÈÜÓÚÒÒ´¼£»²»ÈÜÓÚÂȷ£»¼«Ò×ÈÜÓÚ3NÑÎËáºÍ¼îÐÔÈÜÒº¡£1%Ë®ÖлìÐüÒºpHÖµ4.5-7.0¡£pHµÍÓÚ2ʱÈÜҺЧ¼Û½µµÍ£¬¼îÐÔÏÂѸËÙʧЧ¡£±Ü¹â£¬ÃܱÕÈÝÆ÷Öü´æ¡£ Ph. Eur. 5.5 (Oxytetracycline Hydrochloride). A yellow, hygroscopic, crystalline powder. Freely soluble in water; sparingly soluble in alcohol. Solutions in water become turbid on standing owing to the precipitation of oxytetracycline. A 1% solution in water has a pH of 2.3 to 2.9. Store in airtight containers. Protect from light. ÑÎËáÍÁÃ¹ËØ, EP: Ò»ÖÖ»ÆÉ«Ò×Îü³±¾§Ìå·ÛÄ©£¬¼«Ò×ÈÜÓÚË®£¬ÄÑÈÜÓÚÒÒ´¼¡£Ë®ÈÜÒº·ÅÖÃÒòÎö³öÍÁÃ¹ËØ¶ø±ä»ì¡£1%Ë®ÈÜÒºpHÖµ2.3-2.9¡£±Ü¹â£¬ÃܱÕÈÝÆ÷Öü´æ¡£ USP 29 (Oxytetracycline Hydrochloride). A yellow, odourless, hygroscopic, crystalline powder. It decomposes at temperatures exceeding 180 degrees, and exposure to strong sunlight or temperatures exceeding 90 degrees in moist air causes it to darken. Its potency is diminished in solutions having a pH below 2, and it is rapidly destroyed by alkali hydroxide solutions. Freely soluble in water, but crystals of oxytetracycline separate as a result of partial hydrolysis of the hydrochloride; sparingly soluble in alcohol and in methyl alcohol, and even less soluble in dehydrated alcohol; insoluble in chloroform and in ether. pH of a 1% solution in water is between 2.0 and 3.0. Store in airtight containers. Protect from light. ÑÎËáÍÁÃ¹ËØ, USP: Ò»ÖÖ»ÆÉ«£¬ÎÞ棬Îü³±µÄ¾§Ìå·ÛÄ©¡£³¬¹ý180¡æ·Ö½â£¬±©Â¶ÔÚÇ¿¹â»ò³¬¹ý90¡æÏ³±ÊªµÄ¿ÕÆøÖÐÑÕÉ«±äºÚ¡£µ±ÈÜÒºpHֵСÓÚ2ʱЧ¼Û½µµÍ£¬ÔÚ¼îÐÔÈÜÒºÖÐѸËÙʧЧ¡£¼«Ò×ÈÜÓÚË®£¬µ«ÆäÑÎËáÑβ¿·ÖË®½âÎö³öÍÁÃ¹ËØ¾§Ì壻ÄÑÈÜÓÚÒÒ´¼ºÍ¼×´¼£¬ÎÞË®ÒÒ´¼ÖÐÈܽâ¶È¸üµÍ£»²»ÈÜÓÚÂȷºÍÒÒÃÑ¡£1%Ë®ÈÜÒºpHÖµ2.0-3.0¡£±Ü¹â£¬ÃܱÕÈÝÆ÷Öü´æ¡£ |
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