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【答案】应助回帖
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dreamer2001ly: 金币+5, ★★★★★最佳答案 2014-08-15 10:39:46
sunshan4379: 检索EPI+1, 感谢应助！ 2014-08-15 10:42:14
Analysis of ADAM17 Polymorphisms and Susceptibility to Sporadic Abdominal Aortic Aneurysm
作者:Li, Y (Li, You)[ 1 ] ; Yang, C (Yang, Cheng)[ 2 ] ; Ma, GD (Ma, Guoda)[ 1 ] ; Cui, LL (Cui, Lili)[ 1 ] ; Gu, XF (Gu, Xuefeng)[ 1 ] ; Chen, YY (Chen, Yanyan)[ 1 ] ; Zhao, B (Zhao, Bin)[ 1,3 ] ; Wang, HY (Wang, Haiyang)[ 4 ] ; Li, KS (Li, Keshen)[ 1 ]
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷: 33
期: 5
页: 1426-1438
DOI: 10.1159/000358708
出版年: 2014
查看期刊信息
摘要
Background: Accumulating evidence suggests that the principal TNF-alpha converting enzyme, a disintegrin and metalloproteinase 17 (ADAM17), is involved in the development of human abdominal aortic aneurysm (AAA). However, the association between ADAM17 gene polymorphisms and AAA has not been explored. The present study was aimed to determine the association between ADAM17 promoter polymorphisms and AAA. Methods: A total of 316 patients with AAA and 306 age-matched healthy controls were enrolled in this study. Two ADAM17 promoter polymorphisms (rs12692386 and rs1524668) were determind. Real-time PCR was employed to detect the expression of ADAM17. Results: Overall, there was a significant difference in the frequency of the genotype rs12692386 between the AAA and control subjects (P=0.0096). Furthermore, men with the rs12692386 AG genotype conferred a higher risk of developing AAA (P=0.0058). Additionally, the rs12692386 mutated AG genotype of ADAM17 was significantly associated with increased ADAM17 expression (P=0.035) and TNF-alpha production (P=0.042) in AAA patients. In contrast, the allele frequency of rs1524668 was not statistically associated with AAA. Conclusions: Our findings indicate a positive association between the rs12692386 polymorphism of ADAM17 and AAA. This new knowledge about ADAM17 identifies a role for ADAM17 in the pathophysiology of AAA and has important clinical implications with regard to potential therapeutics. Copyright (C) 2014 S. Karger AG, Basel
关键词
作者关键词:ADAM17; Abdominal aortic aneurysm; Polymorphism
KeyWords Plus:ALPHA CONVERTING-ENZYME; GENOME-WIDE ASSOCIATION; E-DEFICIENT MICE; TNF-ALPHA; ANGIOTENSIN-II; NITRIC-OXIDE; VARIANT; METALLOPROTEINASES; ATHEROSCLEROSIS; SURVEILLANCE
作者信息
通讯作者地址: Li, KS (通讯作者)
Guangdong Med Coll, Affiliated Hosp, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China.
地址:
[ 1 ] Guangdong Med Coll, Affiliated Hosp, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China
[ 2 ] Fu Dan Univ, Dept Cardiac Surg, Zhong Shan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai, Peoples R China
[ 3 ] Guangdong Med Coll, Affiliated Hosp, Inst Neurol, Zhanjiang 524001, Peoples R China
[ 4 ] Harbin Med Univ, Affiliated Hosp 1, Dept Vasc Surg Gen Surg, Harbin 150001, Heilongjiang, Peoples R China
电子邮件地址:haiyangwang811@163.com; likeshen1971@126.com
基金资助致谢
基金资助机构
授权号
National Nature Science Foundation of China
31171219
81271213
81070878
81271214
81300929
81261120404
Natural Science Foundation of Guangdong Province, China
S2012010008222
Science and Technology Innovation Fund of Guangdong Medical College
STIF 201101
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出版商
KARGER, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
类别 / 分类
研究方向:Cell Biology; Physiology
Web of Science 类别:Cell Biology; Physiology
文献信息
文献类型:Article
语种:English
入藏号: WOS:000336493300016
ISSN: 1015-8987
电子 ISSN: 1421-9778
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: AH9VQ
Web of Science 核心合集中的 "引用的参考文献": 41
Web of Science 核心合集中的 "被引频次": 0
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41 引用的参考文献
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