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xiaohezi7844禁言 (知名作家)
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Notch信号传导通路相关疾病的研究进展
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Notch信号传导通路相关疾病的研究进展 Advances in The Research of Diseases Related to Notch Signaling Pathway 中文关键词：Notch，肿瘤，遗传疾病，干细胞 英文关键词：Notch, tumor, hereditary disease, stem cell 赵梅 中文摘要： Notch信号传导通路是影响细胞命运决定的重要通路之一，相邻细胞间通过Notch受体传递信号可以调节包括干细胞在内的多种细胞的分化、增殖和凋亡，影响器官形成和形态发生. Notch信号传导通路中某些分子的基因突变与多种疾病的发生发展有关. 在深入研究Notch信号传导通路的基础上，以其作为靶点设计药物，对于治疗包括肿瘤、CADASIL等遗传性疾病在内的相关疾病，或发展干细胞医疗技术治疗阿尔茨海默症(Alzheimer's disease，AD)、帕金森病、糖尿病等细胞组织功能减退或受损性疾病具有重要的科学意义和应用价值. 英文摘要： Notch signaling pathway plays a vital role in cell fate decisions. Notch signals are transferred among adjacent cells through Notch receptors and their ligands, which can regulate differentiation, proliferation and apoptosis of many cell types including stem cells. They can also influence organ formation and morphopoiesis. Genetic mutations in the Notch signaling pathway are related to the emergence and development of many diseases. Notch signaling pathway is increasingly becoming important drug targets for cancer, hereditary disease such as CADASIL and other related diseases. It is also used to develop stem cell therapeutics to treat age or trauma related degenerative diseases such as Alzheimer's disease, Parkinson disease and diabetes. [ Last edited by xiaohezi7844 on 2008-4-5 at 11:15 ] |
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