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小木虫论坛-学术科研互动平台 » 化学化工区 » 分析 » 化学分析 » 异辛酸钠的定性定量检测方法
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小毛毛311

新虫 (初入文坛)

【答案】应助回帖

理化定性、定量方法就有。
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11楼2014-06-06 17:12:45
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wunanxing-

银虫 (初入文坛)
引用回帖:
10楼: Originally posted by 小木山 at 2014-06-06 15:07:16
离子色谱应该可以  

恩，谢谢，回头试试，成了回来散金币
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12楼2014-06-06 17:38:38
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786486898
13楼2014-06-06 17:39:33
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RXMCDM

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优秀版主优秀版主优秀版主

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
wunanxing-: 金币+20, ★有帮助 2014-06-09 09:54:46
Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate.
Collins MD1, Scott WJ, Miller SJ, Evans DA, Nau H.
Author information 1Institute of Toxicology and Embryopharmacology, Free University Berlin, Germany.
Abstract
A mouse model for the induction of exencephaly with sodium (+/-)-2-ethylhexanoate has been developed using multiple administration regimes. With three consecutive administrations at one-half-day intervals, the most sensitive time to induce exencephaly was Gestational Days 8-9. Using the racemic substance it was determined that the SWV strain was more sensitive to the induction of exencephaly than the C57BL/6NCrlBR strain. The enantiomers of 2-ethylhexanoic acid were separated via preparative HPLC to greater than 99.8% optical purity, and greater than 99% purity according to a gas chromatographic analysis. It was demonstrated that the (R)-enantiomer is a more potent teratogen than the (S)-enantiomer for the induction of exencephaly as well as malformations of other organ systems. Pharmacokinetic analyses for each of the enantiomers were performed in maternal plasma, maternal muscle, and embryo. The pharmacokinetics showed that the peak concentration (Cmax) for both enantiomers in the three compartments was approximately equivalent and was attained within 15 min following the third administration. The area under the concentration versus time curve values for the two enantiomers were approximately 10% higher for the (R)-antipode because of a slightly slower elimination of this compound. There was negligible (or no) racemization of the two enantiomers in the biological samples. The results suggest that teratologic differences in the enantiomers of sodium 2-ethylhexanoate are not due to differences in the concentrations of these antipodes in the embryo, but more likely result from the specific interaction of the enantiomers with chiral molecules in the embryo.
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？
14楼2014-06-06 17:45:23
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wangchun8ha

木虫 (职业作家)

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感谢参与，应助指数 +1
对不起啊，不太了解，建议问问你们师兄师姐或者搜关键词，看看相关文献
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要做就做最好！
15楼2014-06-06 17:58:02
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wunanxing-

银虫 (初入文坛)
引用回帖:
15楼: Originally posted by wangchun8ha at 2014-06-06 17:58:02
对不起啊，不太了解，建议问问你们师兄师姐或者搜关键词，看看相关文献

我是第一个吃螃蟹的，和师兄师姐研究的完全不一样，不管怎么说谢了
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16楼2014-06-07 10:36:32
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wunanxing-

银虫 (初入文坛)
引用回帖:
11楼: Originally posted by 小毛毛311 at 2014-06-06 17:12:45
理化定性、定量方法就有。

我查了查，还是不懂
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17楼2014-06-07 10:37:57
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wunanxing-

银虫 (初入文坛)
引用回帖:
13楼: Originally posted by 786486898 at 2014-06-06 17:39:33
18楼2014-06-07 10:45:35
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wunanxing-

银虫 (初入文坛)
费姚永芬: 不可求助文献奥 2014-06-07 16:58:24
引用回帖:
14楼: Originally posted by RXMCDM at 2014-06-06 17:45:23
Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate.
Collins MD1, Scott WJ, Miller SJ, Evans DA, Nau H.
Author information 1Institute of Toxicology and Embryopharma ...

先谢谢啦，摘要里边只说了通过HPLC和气相色谱检测异辛酸纯度，没有说怎么检测异辛酸钠啊，有文献全文么？
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19楼2014-06-07 11:04:39
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亮亮xmlgxy

至尊木虫 (知名作家)

像向阳花一样绽放

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
wunanxing-: 金币+20, ★有帮助 2014-06-09 09:55:05
异辛酸钠，相应的文献感觉比较少啊
http://www.sciencedirect.com/sci ... i/S0040403998015469
http://www.sciencedirect.com/science/article/pii/0041008X9290195X
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阳光打在你的脸上，温暖留在我们心头
20楼2014-06-08 20:04:44
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