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321wangke321

金虫 (正式写手)

[交流] 有没有虫友做过转录组和代谢组的关联分析的?

委托公司做的转录组的结果出来的,准备将一些代谢产物测一下,想将代谢产物和转录组的结果进行关联分析,但是不知从何下手,请高人指点!!!
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一个呀路

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同求,最近也在找这方面的文章
4楼2014-05-14 21:12:43
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wizardfan

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只做过转录和蛋白的关联。
代谢受到的调控太多了,很难。
2楼2014-05-10 06:39:04
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321wangke321

金虫 (正式写手)

引用回帖:
2楼: Originally posted by wizardfan at 2014-05-10 06:39:04
只做过转录和蛋白的关联。
代谢受到的调控太多了,很难。

我看到一篇文献是转录和脂质的关联,但是最多的是转录和蛋白的关联。关键现在不知道怎么关联?有没有一些教程?老板安排的任务,但是完全忽略了任务的艰巨性啊
王者风范,一切皆有可能。
3楼2014-05-10 09:59:23
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广之

金虫 (正式写手)


小木虫: 金币+0.5, 给个红包,谢谢回帖
可以尝试下面的数据分析处理程序:
ProMeTra
https://prometra.cebitec.uni-bie ... .cgi?login=prometra
参考文献:
Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example
http://www.biomedcentral.com/1752-0509/3/82

IMPaLA
http://impala.molgen.mpg.de/
参考文献:
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
http://www.biomedcentral.com/1471-2407/10/628
Paintomics
http://www.paintomics.org/cgi-bin/main2.cgi
参考文献:
Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008637/
以 transcriptomics 和 metabolomics为关键词,可以检索到不少文献的呢,比如:
Integration of transcriptomics and metabolomics for understanding of global responses to nutritional stresses in Arabidopsis thaliana
http://www.pnas.org/content/101/27/10205.full

Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer
http://clincancerres.aacrjournals.org/content/19/18/4983.short

Merging transcriptomics and metabolomics - advances in breast cancer profiling
http://www.biomedcentral.com/1471-2407/10/628

Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways
http://link.springer.com/article/10.1007%2Fs11306-014-0713-3

Integrative Analysis of Metabolomics and Transcriptomics Data: A Unified Model Framework to Identify Underlying System Pathways
http://journals.plos.org/plosone ... ournal.pone.0072116

Integrative Analysis of Transcriptomics, Proteomics, and Metabolomics Data of White Adipose and Liver Tissue of High-Fat Diet and Rosiglitazone-Treated Insulin-Resistant Mice Identified Pathway Alterations and Molecular Hubs
http://pubs.acs.org/doi/abs/10.1021/pr5005828
6楼2015-03-02 19:08:28
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