| 查看: 1886 | 回复: 10 | |||
[交流]
热休克蛋白90α 知识普及
|
|
中央新闻报道了清华课题组首次在国际上证明，人热休克蛋白Hsp90α（以下简称人90α）为一个全新的肿瘤标志物，并研发出定量检测试剂盒。目前，该试剂盒已获得国家第三类（最高类别）医疗器械证书，并通过欧盟认证。 建议大家合力普及一下这方面的知识！！ |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : PNAS-2009-Wang-21288-93__HSP_90a.pdf
- 附件 2 : J_Immunol-2009-Houlihan-7451-8__HSP_90a.pdf
2013-11-21 15:13:45, 1.81 M
2013-11-21 15:14:25, 2.72 M
» 猜你喜欢
时间戳 2019-08-09 12:49:30（火狐），有一样或更早的吗？
已经有39人回复
-
科学传播中心推送邮件
已经有10人回复
-
生殖系统/围生医学/新生儿论文润色/翻译怎么收费?
已经有64人回复
-
投稿系统需要连接ORCID，但是ORCID显示“未验证”
已经有2人回复
-
求问什么温度计可以测量小鼠肛温（低于32℃）？
已经有3人回复
-
求一些蛋白保护性上调，最后随着疾病发展又下降的文献！
已经有0人回复
» 本主题相关商家推荐: (我也要在这里推广)
2楼2013-11-19 15:10:29
3楼2013-11-19 17:50:33
4楼2013-11-19 18:38:09
5楼2013-11-19 19:43:05
6楼2013-11-19 20:03:30
7楼2013-11-19 20:25:27
★
小木虫: 金币+0.5, 给个红包，谢谢回帖
小木虫: 金币+0.5, 给个红包，谢谢回帖
| The molecular acclimation of intertidal green macroalga Ulva fasciata Delile to high salinity stress were examined by the construction of a forward cDNA library via the suppressive subtractive hybridization between 30‰ and 90‰ (24 h) and by the time course dynamics of several abundantly expressed genes. Among the genes with known sequences, the expressed sequence tags are abundant in the function of protein synthesis (ribosomal protein) and destination. The cDNAs of ATP-dependent Clp protease (UfClpC), 20S proteasome β-subunit type 1 domain (UfPbf1), ubiquitin-conjugating enzyme E2 I (UfUbc9), and heat shock protein 90A (UfHsp90A) were cloned. UfClpC transcript increased 3 h after 90‰ treatment, followed by a decrease, while UfPbf1 and UfUbc9 transcripts increased after 12 h and decreased at 48 h. The transcripts of UfHsp90A increased 1 h after 90‰ treatment, followed by a drop and to the control level at 48 h. Protease activity increased 3 h after 90‰ treatment and decreased to the control level at 48 h. H₂O₂ contents increased 1 h after 90‰ treatment and then remained unchanged, but protein carbonyl group contents increased after 48 h. The treatments of reactive oxygen species scavengers partially alleviated 90‰ damage (partial growth rescue) and suppressed the increases in H₂O₂ content, protein carbonyl group content, protease activity, and UfClpC, UfPbf1, UfUbc9, and UfHsp90A transcripts by 90‰. The induction of specific chaperones and proteases at the molecular level for protein quality control can be considered as one of the molecular mechanisms of hypersalinity acclimation in U. fasciata. |
8楼2013-11-21 11:02:02
9楼2013-11-21 14:13:31
10楼2013-11-21 15:11:44
11楼2014-06-05 08:42:58