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Ericagan木虫 (小有名气)
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chemokine receptor与chemotaxis 已有1人参与
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| 现阅读文献，发现了这两个词，不太了解它们的关系，请问各位大神，能否详细解释一下细胞表面趋化因子的缺失怎样检测以及趋药性的检测是否为同一实验？ |
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凌波丽
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小木虫: 金币+0.5, 给个红包，谢谢回帖
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你是说药物分子穿透膜？还是引起了第二信使？不过我认为这样两种方法的确是研究膜蛋白的具体功能的有效方法。我个人认为：完全依靠流式细胞仪大概比较难以深入下去，即使借助单细胞分析方法也不是很容易。 而利用大分子与蛋白质相互作用，大分子与蛋白质相互作用，无论是确定新的信号途径或原有的信号通路的改变，还是确定具体两两相互作用的大小分子的相互作用而产生的精细结构变化与功能改变，Cross talk，或者生物分子相互作用网络的确定或者变化等方面都可以有众多的可深入挖掘之处。如果把这些和穿透膜技术联系到一起，至少从穿透膜技术比用流式更容易到达目的。 |
9楼2013-06-13 22:35:35
凌波丽
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小木虫: 金币+0.5, 给个红包，谢谢回帖
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Chemotaxis From Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Chemotaxis Chemotaxis is the phenomenon whereby somatic cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (for example, glucose) by swimming towards the highest concentration of food molecules, or to flee from poisons (for example, phenol). In multicellular organisms, chemotaxis is critical to early development (e.g. movement of sperm towards the egg during fertilization) and subsequent phases of development (e.g. migration of neurons or lymphocytes) as well as in normal function. In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis. Positive chemotaxis occurs if the movement is toward a higher concentration of the chemical in question. Conversely, negative chemotaxis occurs if the movement is in the opposite direction. Chemokine receptor From Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Chemokine_receptor Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic "DRY" motif in the second intracellular domain. Chemokine receptors are usually linked to a G-protein through which they signal Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine.[1][2] There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. |
2楼2013-06-09 18:10:08
凌波丽
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3楼2013-06-09 18:12:30
凌波丽
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4楼2013-06-09 18:20:16
