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yin198716新虫 (正式写手)
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| Paralleling vascular development, Dll4 expression in tumor vessels appears to be directly regulated by VEGF; thus Dll4 expression levels in tumors have been found to correlate with those of VEGF. In humans, Dll4 expression was analyzed in tumors from kidney, bladder, colon, brain and breast.Robust Dll4 expression was observed specifically in the tumor vasculature in all of these tumor types, whereas Dll4 expression was low to undetectable in the vasculature of adjacent normal tissue. |
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yin198716: 金币+3, 翻译EPI+1 2013-02-27 11:16:26
phu_grassman: 金币+2, it\\\'s really kind of you. 2013-02-27 13:34:58
sltmac: 金币+7, 感谢应助 2013-03-27 08:46:15
yin198716: 金币+3, 翻译EPI+1 2013-02-27 11:16:26
phu_grassman: 金币+2, it\\\'s really kind of you. 2013-02-27 13:34:58
sltmac: 金币+7, 感谢应助 2013-03-27 08:46:15
| 与血管发育相似，看来肿瘤血管中的Dll4 表达量直接受VEGF调节；因而，人们已发现肿瘤中的 Dll4 表达水平跟VEGF水平相关。笔者分析了人体肾脏、膀胱、结肠、脑和胸等部位肿瘤中的 Dll4 表达量。在这几种肿瘤的肿瘤脉管中都具体发现了很强的Dll4 表达，而在相邻正常组织的脉管中，Dll4 表达量则低至无法检测。 |
2楼2013-02-27 10:39:57