|
|
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ chaperones: 金币+10, 翻译EPI+1, ★有帮助 2012-11-02 16:15:44 phu_grassman: 金币+3, thanks for your time. 2012-11-02 21:03:29
太难,只能翻译一半:
Rab13 was originally described as localizing to tight junctions in polarized epithelial cells and to vesicular structures in non-polarized cells (Zahraoui et al. 1994). Overexpression of the constitutively active, GTP-bound form of Rab13 has been shown to inhibit the assembly of tight junctions (Marzesco et al. 2002). Rab13 affects the transport of Claudin-1 to the cell surface in non-polarized BHK cells and regulates the endocytic recycling of occludin in both
fibroblastic BHK and epithelial MTD-1A cells (Marzesco et al. 2002; Yamamoto et al. 2003; Morimoto et al. 2005).
Rab13 最初被认为用来固定极化上皮细胞的紧密连接或非极化上皮细胞的囊状结构 (Zahraoui et al. 1994). Rab13 的GTP粘合形态能够抑制紧密连接的结合Marzesco et al. 2002),但过于强调了其组成活性。在非极化BHK细胞中,Rab13能够影响Claudin-1进入细胞表面;在成纤维BHK细胞和 MTD-1A 上皮细胞中,Rab13能够调节occludin的胞吞循环。(Marzesco et al. 2002; Yamamoto et al. 2003; Morimoto et al. 2005). |
|