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[×ÊÔ´] [Ò©Îﻯѧ] Bioisosteres in Medicinal Chemistry

Bioisosteres in Medicinal Chemistry



http://onlinelibrary.wiley.com/book/10.1002/9783527654307

About The Product

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.
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  • ¸½¼þ 1 : BioisosteresinMedicinalChemistry.pdf
  • 2012-10-13 14:19:27, 2.38 M

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