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[×ÊÔ´] Chem. Rev. ×ÛÊö-¡°Magnetic Nanoparticles¡±-´ÅÐÔÄÉÃ׿ÅÁ£µÄºÏ³É¼°ÉúÎïÓ¦ÓÃ


       ´ÅÐÔÄÉÃײÄÁÏÊÇÄÉÃ×ÁìÓòµÄÑо¿ÈȵãÖ®Ò»¡£¾«È·¿ØÖƺϳÉÌõ¼þºÍ±íÃæÐÞÊζԴÅÐÔÄÉÃ׿ÅÁ£¶øÑÔÊǷdz£ÖØÒªµÄ£¬ÒòΪËü»á¾ö¶¨²ÄÁϵÄÎïÀí»¯Ñ§ÊôÐÔ£¬½ø¶ø¾ö¶¨ÆäÓ¦Óᣱ¾ÎÄ×ÛÊöÁË´ÅÐÔÄÉÃײÄÁϵĺϳɷ½·¨¡¢ÎïÀí»¯Ñ§ÌØÕ÷¼°ÆäÔÚÉúÎïÒ½Ò©·½ÃæµÄÓ¦Óá£È«ÎÄ61Ò³£¬ÒýÎÄ710ƪ¡£
1. Introduction
2. Design of Magnetic Colloids
2.1. Synthesis Strategies
2.1.1. Electron Beam Lithography
2.1.2. Gas-Phase Deposition
2.1.3. Sol¨CGel Method
2.1.4. Oxidation Method
2.1.5. Chemical Coprecipitation
2.1.6. Hydrothermal Method
2.1.7. Flow Injection Method
2.1.8. Electrochemical Method
2.1.9. Aerosol/Vapor-Phase Method
2.1.10. Sonochemical Decomposition Method
2.1.11. Supercritical Fluid Method
2.1.12. Synthesis Using Nanoreactors
2.1.13. Microbial Method
2.1.14. Synthesis of Metal-Doped Iron Oxide Nanoparticles
2.2. Stabilization Procedures
2.2.1. Use of Stabilizing Surface Coating Materials
2.2.2. Encapsulation into Polymeric Shells
2.2.3. Encapsulation into Liposomes
3. Physicochemical Properties and Physicochemical Characterization
3.1. Geometry
3.2. Structure
3.3. Surface Charge
3.4. Surface Thermodynamics
3.5. Magnetism
3.6. Colloidal Stability
4. Pharmacokinetics, Biodistribution, And Biological Fate
4.1. Influence of the Size
4.2. Influence of the Surface Charge
4.3. Influence of the Administration Route
4.4. Factors Influencing the Tissue/Cell Penetration
5. Toxicity and Biocompatibility
5.1. In Vitro Evaluation of the Toxicity
5.1.1. Influence of the Surface Coatings
5.1.2. Influence of the Size
5.1.3. Influence of the Surface Charge
5.2. In Vivo Evaluation of the Toxicity
5.2.1. Toxicity after Intravenous Administration
5.2.2. Toxicity after Intraperitoneal Administration
5.2.3. Toxicity after Subcutaneous Administration
6. Disease Therapy
6.1. Construction of Magnetically Guided Nanoparticles for Drug Delivery
6.2. Chemotherapy
6.2.1. Systemic Chemotherapy
6.2.2. Local Chemotherapy
6.2.3. Oral Delivery
6.2.4. Stimuli-Sensitive Drug Delivery
6.2.5. Miscellaneous Applications
6.3. Magnetofection (Gene Delivery)
6.3.1. In Vitro Magnetofection
6.3.2. In Vivo Magnetofection
6.4. Magnetically Guided Radioimmunotherapy
6.5. Magnetically Guided Photodynamic Therapy
6.6. Magnetic Fluid Hyperthermia
6.6.1. Preclinical Evaluation of Magnetic Fluid Hyperthermia
6.6.2. Clinical Evaluation of Magnetic Fluid Hyperthermia
7. Magnetic Resonance Imaging
7.1. Organ/Tissue Imaging
7.1.1. Lymph Node Imaging
7.1.2. Imaging of Atherosclerotic Plaques
7.1.3. Imaging of Inflammatory Response in Central Nervous System Disorders
7.1.4. Imaging of Macrophage Infiltration in Transplanted Organs
7.1.5. Imaging of Macrophage Infiltration in Knee Joints
7.1.6. Imaging Using Ligand-Functionalized Superparamagnetic Iron Oxide Nanoparticles
8. Cell Labeling and Imaging
8.1. Imaging of Transplanted Stem Cells
8.2. Imaging of Transplanted Pancreatic Islet Cells
8.3. Imaging of Dendritic Cells
8.4. Imaging of Apoptotic Cells
9. Tissue Engineering
9.1. Engineering of Heterotypic Cell/Tissue Constructs
9.2. Scaffold-Based Tissue Engineering
9.3. Scaffold-Free Engineering of Three-Dimensional Tissue Constructs
10. Miscellaneous Applications
10.1. Cell Separation and Cell Sensing
10.1.1. Separation of Bacterial Cells And Mammalian Cells
10.1.2. Separation of Viruses
10.1.3. Magnetic-Relaxation Switches
10.2. Separation of Biochemicals
10.3. Enzyme/Protein Immobilization
10.4. Bioanalysis and Immunoassays
10.5. Separation of Heavy Metal Contaminants from Mixtures
11. ConclusionsMagnetic Nanoparticles.jpg

[ Last edited by dut_ameng on 2012-10-10 at 09:47 ]
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