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zhuimenglx银虫 (小有名气)
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[求助]
求助医药方面的论文摘要的翻译，英译汉，非常感谢！
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Subclinical Hyperthyroidism and the Risk of Coronary Heart Disease and Mortality Background Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Methods Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 participants from 6 cohorts with available data, and incident AF was analyzed in 8711 participants from 5 cohorts. Euthyroidism was defined as thyrotropin level between 0.45 and 4.49 mIU/L and endogenous subclinical hyperthyroidism as thyrotropin level lower than 0.45 mIU/L with normal free thyroxine levels, after excluding those receiving thyroid-altering medications. Results Of 52 674 participants, 2188 (4.2%) had subclinical hyperthyroidism. During follow-up, 8527 participants died (including 1896 from CHD), 3653 of 22 437 had CHD events, and 785 of 8711 developed AF. In age- and sex-adjusted analyses, subclinical hyperthyroidism was associated with increased total mortality (hazard ratio [HR], 1.24, 95% CI, 1.06-1.46), CHD mortality (HR, 1.29, 95% CI, 1.02-1.62), CHD events (HR, 1.21; 95% CI, 0.99-1.46), and AF (HR, 1.68; 95% CI, 1.16-2.43). Risks did not differ significantly by age, sex, or preexisting cardiovascular disease and were similar after further adjustment for cardiovascular risk factors, with attributable risk of 14.5% for total mortality to 41.5% for AF in those with subclinical hyperthyroidism. Risks for CHD mortality and AF (but not other outcomes) were higher for thyrotropin level lower than 0.10 compared with thyrotropin level between 0.10 and 0.44 mIU/L (for both, P value for trend, .03). Conclusions Endogenous subclinical hyperthyroidism is associated with increased risks of total, CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L. |
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【答案】应助回帖
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爱与雨下: 金币+2 2012-04-29 08:07:58
爱与雨下: , 欢迎常来~！ 2012-04-29 08:08:11
zhuimenglx: 金币+10, ★有帮助, 谢谢！ 2012-05-01 15:23:13
爱与雨下: 金币+2 2012-04-29 08:07:58
爱与雨下: , 欢迎常来~！ 2012-04-29 08:08:11
zhuimenglx: 金币+10, ★有帮助, 谢谢！ 2012-05-01 15:23:13
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从一群人得亚临床感染和冠心病的情况，我们得出了这样一个结论亚临床感染与冠心病是相互抵制的。我们想要得出冠心病的死亡率。冠心病的发病是内生的。我们对52674位参与者作冠心病的调查，其中只有十名病例。从22437位调查者中我们发现了6名冠心病患者，同时对8711位参与者进行了AF的分析。甲状腺机能正常意味着治疗水平在0.45到4.49mIU/L 的范围内，同时内生亚临床感染的治疗水平在0.45 0.45 mIU/L ，即维持在正常的治疗水平内。 我们对52674位参与者进行分析，其中有2188（4.2%）位.存在亚临床感染。共有8527位参与者最终死亡，3653位参与者会发生CHD。从年龄和性别分析，亚临床感染(hazard ratio [HR], 1.24, 95% CI, 1.06-1.46)的总死亡率增加，CHD(HR, 1.29, 95% CI, 1.02-1.62)死亡，AF情况为(HR, 1.68; 95% CI, 1.16-2.43)，这些与年龄和性别的关系不大。或者潜在的冠心病与进一步的冠心病发病因素有关。在全部死亡中有14.5%是死于冠心病。 与正常治疗水平相比CHD死亡治疗水平更高。 总之，CHD,AF都会内生亚临床感染，从面使CHD和AF的治疗水平降低。 |
2楼2012-04-28 18:38:53