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【答案】应助回帖
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爱与雨下: 金币+2 2012-04-29 08:05:09
爱与雨下: , 欢迎常来~！ 2012-04-29 08:05:19
zhuimenglx: 金币+100, 翻译EPI+1, ★★★很有帮助, 谢谢！ 2012-05-01 15:22:11
Application of tumor markers in serum in the assisted diagnosis of lung cancerPurposeExplore the application value of five kinds of serum tumor markers in assisted diagnosis of lung cancer , and select the best combination of serum tumor markers .Method we used the Enzyme-linked immunosorbent assay ( EL1SA ) to detecte the neuron-specific enolase (NSE) in serum , gastrin-releasing peptide precursor (pro - GRP) the cytokeratin l9 ( CYFRA21 -1 ) , p53 antibody and the level of content of carcinoembryonic antigen (CEA).All of above are from 170 cases of lung cancer patients and 50 healthy controls and 60 cases of patients with benign lung disease
ResultThe level of five kinds of tumor markers in serum from lung cancer patients were significantly higher than the group of healthy individuals and benign lung disease group , the difference was statistically significant ( P <0.01 ) . The level of NSE and pro -GRP of in small cell of lung cancer was significantly higher than other types of lung cancer ( P <0.01 ) , the level of CYFRA21 -1 in squamous cancer was significantly higher than other types of lung cancer ( P <0.01 ) .The specificity of p53 antibody was 100 %, the sensitivity that using NSE, pro -GRP to detect small cell lung cancer was significantly higher than other types of lung cancer ( P <0.01 ) , the sensitivity that using CYFRA21 -1 to detect squamous carcinoma was significantly higher than other types of lung cancer ( P < 0.01 ) . After the combination of Five kinds of serum tumor markers , the sensitivity was significantly higher than any of the individual tumor markers ( P <0.01 ) .
Conclusion Five kinds of serum tumor marker have a certain clinical significances for assisted diagnosis of lung cancer. NSE and pro -GRP can be used asr forof small cell lung cancer , CYFRA21 -1 , CEA and p53 antibody can be used as the preferred marker for joint detection of non-small cell lung cancer . p53 antibody has a high specificity for assisted diagnosis of lung cancer ,CYFRA21 - 1 has a certain effects on assisted diagnosis of squamous cancer
【Keywords 】 tumor markers ; lung neoplasms / diagnosis ; non - small cell lung cancer / diagnosis |
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