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sltmac: ½ð±Ò+1 2012-04-11 09:56:40
sltmac: ½ð±Ò+23 2012-04-26 10:44:25
sltmac: »ØÌûÖö¥ 2012-04-26 10:44:33
There are many papers about how to construct dihydro-pyrazole ring compound. But triditional methods have a lot of disadvantages such as complex procedures, expensive reagents, low productivity, ect. Multi-component one-pot method is always hot research topic. This work employed this method to synthesize 4,5 - dihydro-pyrazole derivatives using hydrazine, allyl and aldehyde component as subtrate. The catalyst used was Cu(OTf)2. This method went through the continuous process of  Mannich/cyclization/oxidation, thus obtained 1,3,5 - trisubstituted 4,5 - dihydro-pyrazole via one-pot method with no need of intermediates separation. Trifluoromethyl sulfonic acid copper catalyzed three reaction processes as a single catalyst. This method is highly efficent in constructing dihydro-pyrazole ring due to its advantages including mild reaction conditions, simple operation, required raw materials cheap and easily available, and wide range of substrates.
2Â¥2012-04-10 22:38:01
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YH_ChowF

ľ³æ (ÕýʽдÊÖ)

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Mally89: ½ð±Ò+1, ¸ÐлӦÖú£¡~»¶Ó­³£À´£¡~ºðºð£¡~\(^o^)/~ 2012-04-20 12:57:21
smth: ½ð±Ò+2, ·­ÒëEPI+1 2012-04-22 10:24:09
sltmac: ½ð±Ò+50 2012-04-26 10:44:13
It has been reported how to construct pyrazoline cyclic compound in many literatures, but the traditional method has many disadvantages, such as various step, expensive used catalyst, and low yield. The multi-component one-pot has always been a hot research topic in the chemical research field. The paper synthetizes 4, 5- pyrazoline derivatives from hydrazine, alkene, and aldehyde by one-pan. The used catalyst is Cu (OTf) 2. The method passes through continuous Mannich/cyclization/oxidation process, and has no need for separating intermediates, which can prepare 1-3, 5-tris 4,5- pyrazoline. Tri-fluoro methyl sulfonic acid copper is used as single catalyst, simultaneity catalyzing three reaction processes. It has the advantages of mild reaction condition, simple operation, low price of raw material, and wide scope of application for substrate. It is an effecient method for constructing pyrazoline.
3Â¥2012-04-15 17:05:47
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

lxg133298

ÈÙÓþ°æÖ÷ (ÎÄѧ̩¶·)

Stay Hungry. Stay Foolish.

ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷

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¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
Mally89: ½ð±Ò+1, ¸ÐлӦÖú£¡~»¶Ó­³£À´£¡~ºðºð£¡~\(^o^)/~ 2012-04-20 12:57:27
smth: ½ð±Ò+5 2012-04-22 10:24:19
sltmac: ½ð±Ò+20 2012-04-26 10:44:31
There have reported so many papers about how to construct dihydro-pyrazole ring compound so  far.
however,   because of these triditional methods have a lot of disadvantages such as complex procedures, expensive reagents, low productivity, ect. It is still a challenge for us to find a better approach to
solve that problem£¡The one-pot method  of  Multi-component  is a very  attractive hot research field!
In this paper, we employed this method to synthesize 4,5 - dihydro-pyrazole derivatives using hydrazine, allyl and aldehyde component as subtrate. The catalyst used was Cu(OTf)2. This method underwent a continuous process of Mannich/cyclization/oxidation, thus obtained 1,3,5 - trisubstituted 4,5 - dihydro-pyrazole via one-pot method with no need of intermediates separation. Trifluoromethyl sulfonic acid copper catalyzed three reaction processes as a single catalyst. .The mild reaction conditions, simple operation, the required raw materials, cheap and easy to get, the substrate applicable to a wide range, is an efficient build dihydro-pyrazole ring.




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4Â¥2012-04-16 17:35:20
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