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小木虫论坛-学术科研互动平台» 学术交流区» 论文翻译 » 论文翻译求助完结子版 » 润色 生物学
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爱与雨下(金币+1): 感谢你的支持！ 2011-09-01 15:37:23
huojinlong8610(金币+10, 翻译EPI+1): 2011-09-01 16:17:31
sltmac(金币+35): 欢迎常来~~ 2011-09-07 07:48:00
The signal peptide prediction performed by SignalP 3.0 on the basis of a combination of several artificial neural networks and hidden Markov models revealed that BMI RBKS contained a potential signal peptide with 58.8% probability. However, （加when）we search（时态是不是应该一致） signal peptide using human and cattle RBKS protein sequences by SignalP 3.0, there is not a singal peptide found, the probability is low 1%（as low as 1%）. The reason about (The reason for the )difference and conflict of pig , human and cattle RBKS signal peptide need further study later(needs further study, later可删去).
      RBKS was discovered more than 50 years ago, and there has been much progress in understanding this important enzyme within the last decade. But the molecular mechanisms of which actors and how target it （这一句可否提供中文翻译）remain a central unresolved problem for biochemists and pharmacologists. For this reason, the homology modeling of the BMI RBKS protein was carried out using human ribokinase (2fv7 Chain: B) as the template. Our results indicate that the conserved domain (RBKS, 17-323AA) of pig RBKS protein mainly exists（exist 为不及物动词，是不是以这两种形式存在，可以在前面加in the form of） αβα sandwich domain and β-barrel. It suggests that these domains may play a pivotal role in RBKS activity. This first pig structural model of RBKS should prove useful reference in designing studies aimed at understanding how RBKS interacts with unknown protein partners for explaining its various functions. ,
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