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重金悬赏中译英一段，自噬相关，不甚感激！！！
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A药具有诱导自噬的作用。近年来对自噬的研究十分广泛，在正常的多细胞生物体中，进行正常的能量代谢和生物活动时，会产生一些不必要的老化的细胞器或者蛋白以及代谢物，自噬在清除这些代谢废物进而回收能量为细胞正常运转所用中发挥着重要作用，一旦自噬作用受影响，细胞当中一些正常循环不能有效实现，正如精密调控的程序出现累积错误，系统必然出现问题，生物体自发性肿瘤的几率就增多。一些研究结果发现， 肿瘤发生与自噬缺陷有关。 自噬基因Beclin-1为杂合子的小鼠发生自发性恶性肿瘤的风险增高； 乳腺癌、 卵巢癌和前列腺癌以及白血病患者Beclin-1等位基因缺失的比例高于健康人。A药作为中药中特有的成分，从药用植物当中提取出来，具有一定的抗肿瘤活性，其具体对于肿瘤细胞的其它作用却鲜有研究。为研究A药在抗肿瘤作用中所发挥的作用提供了新的靶点和研究方向。 [ Last edited by 前世今生 on 2011-7-26 at 13:25 ] |
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shirongjiu
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sltmac(金币+2): 感谢交流~~ 2011-08-03 00:15:17
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sltmac(金币+50): 2011-08-05 15:17:43
sltmac(金币+25): 欢迎常来本版交流~~ 2011-08-05 15:17:53
| Drug A could induce autophagy. There has been a wide range of research on autophagy in recent years. In normal multicellular organisms, some unnecessary aged organelles or proteins and metabolites will be produced during the normal energy metabolism and bioactivities. Autophagy plays an important role in eliminating these metabolic wastes and recovering the energy to maintain the normal functions of cells. However, some of the normal cell cycles will not proceed effectively in case the autophagy is disturbed, just as the cumulative errors occur in precisely regulated programs; hence, problems will inevitably emerge, e.g. the probability of spontaneous tumors will increase in organisms. Some studies have shown that tumorigenesis is associated with autophagy defects. For instance, the Beclin-1 heterozygous mice were reported to develop a high incidence of spontaneous tumors; loss of Beclin-1 allele in patients with breast cancer, ovarian cancer, prostate cancer or leukemia patients is higher than in healthy people. Drug A, as a specific component of traditional Chinese medicine, is extracted from some medicinal plant with some anti-tumor activity. However, its other specific effects on the tumor cells have been rarely investigated. Autophagy provides a new target and research direction for the study of anti-tumor effect of drug A. |
6楼2011-07-27 08:59:26
8814402
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前世今生(金币+300, 翻译EPI+1): 2011-07-27 10:17:16
sltmac(翻译EPI-1): EPI发放错误~~ 2011-08-03 00:14:57
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sltmac(金币-30): 金币发放错误~ 2011-08-03 08:55:26
前世今生(金币+300, 翻译EPI+1): 2011-07-27 10:17:16
sltmac(翻译EPI-1): EPI发放错误~~ 2011-08-03 00:14:57
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sltmac(金币-30): 金币发放错误~ 2011-08-03 08:55:26
| 认领。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。 |
2楼2011-07-26 16:46:20
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| A drug processes an effect of induced autophagy. In recent years, there are a wide rang of researches on the autophagy, in normal multicellular organisms, normal energy metabolism and biological activity will produce some unnecessary and aged organelles, proteins or metabolites. The autophagy plays an important role in cleaning these metabolic wastes for energy recovery and then used for the normal functioning of cells. Some of the normal cell cycles can not be effectively achieved when the autophagy was influenced, just as the precise and regulatory programs occurs cumulative errors, the system will inevitably emerge problems, the probability of spontaneous tumors in organisms will increase. Some studies show that there is a close relation between tumorigenesis and autophagy defects. For instance, if the autophagy gene Beclin-1 of mice is heterozygous, it’s much easier for them to get spontaneous malignant tumor. The loss of Beclin-1 allele for breast cancer, ovarian cancer, prostate cancer and leukemia patients is higher than healthy people. A drug, which contains specific components of traditional Chinese medicine, is extracted from the medicinal plant with some anti-tumor activity. However, its specific affect to the tumor cells is rarely studied. This provides a new target and research direction for the study of anti-tumor effect of A drug. |
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前世今生3楼2011-07-26 20:07:17
LittleBush
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sltmac(金币+2): 感谢应助~ 2011-07-27 00:04:13
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sltmac(金币+40, 翻译EPI+1): 感谢应助，欢迎常来~~ 2011-08-05 15:17:17
| Drug A has the effect to induce autophagy.Autophagy has drawn great attention in research community in recent years.In the normal multi-cellular organisms，during the process of energy metabolism and biological activities ,there will produce some unnecessary organelles or proteins as well as metabolites and autophagy can play a pivotal role in clearing up such wastes in order to provide energy for the normal cellular functions.And once there is something wrong with the autophagy，some normal cellular processes will fail .Just as that the accumulated errors to a delicately regulated program will result in systematic problems ,the abnormality with autophagy can led to increased likelihood for the spontaneous tumorigenesis.Now,amounting evidence shows that there is close association between autophagy defect and tumorigenesis One study showed that in the heterozygous autophagy gene Beclin-1 mice,the odds of spontaneous malignancies increased and other studies demonstrated that the probability of loss of allelic Beclin-1 is higher in the breast cancer ,ovary cancer ,prostate cancer and leukemia patients than in the otherwise healthy control population.Drug A can be extracted from medicinal herbs and has anti-cancer effects but the specific mechanism for its anti-cancer effects is rarely studied.The autophagy can be a novel target and direction for the study of anti-cancer role of drug A. |
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4楼2011-07-26 21:15:11
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