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蓝天306(金币+149, 翻译EPI+1): 非常感谢！！！！ 2011-04-07 12:56:19
This article is a review on the pharmacological effects and clinical applications of statins (reductase inhibitors of hydroxymethyl coenzyme A ).
based on the pharmacology and production status of lovastatin-one of the important member of statins, there is a great market demand, and even better prospects.
The development of technology put a higher standard on the pharmaceutical products.
USP has the requirement that unless there are enough evidences to prove that the impurity has the same pharmacological effects as the principal component, and still the impurity has no toxicological effects, the total content of impurities in the product should be less than 1.0%. Single impurity content should be less than 0.2%.
China is the major producer of raw materials of lovastatin.
In order to meet the new national pharmacopoeia requirements of lovastatin, there is a need to conduct in-depth study of impurities in lovastatin.
First of all, compounds are obtained and their structures should be identified, and their properties are studied. And then make clear in reaction steps these impurities are generated.
Another problem is how to reduce the production of the impurities,and how to remove them.
At the same time, get enough monomer impurity in the compounds to conduct pharmacological and toxicological studies.
The main idea of this paper is purification of the impurity in the fermentation products of lovastatin and identification of their structure.
In this study the raw materials is the crystal liquor of lovastatin in the final step of extraction and purification.
And then take measures like silica gel column chromatography, silica gel prepared by TLC, RP-silica gel column chromatography, semi-preparative HPLC and other methods to get 6 isolated compounds.
And Comprehensive usage of spectrum study methods, such as FT-IR, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC and MS can be taken to identify their structures. These compounds are:
[ Last edited by ringzhu on 2011-4-7 at 12:49 ] |
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