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wanss

铁虫 (正式写手)


[交流] 【求助】支架材料的制备方法

看到一篇文献,制备支架材料,叙述如下:
Scaffold preparation by solid–liquid phase separation: a known amount of polylactide was dissolved in dioxane to form solutions with desired concentrations. Four different concentrations of PLLA solution (0.5, 1.0, 3.0 and 5.0% w/v) were frozen and maintained over 2 hr to induce solid–liquid phase separation completely. The clear 5% PLLA solutions were poured into aluminum foil molds (4x4 cm2) which were fast-frozen in liquid
nitrogen, ice-water bath or freezer, respectively, and then were maintained at those
temperatures for over 2 hr to induce solid–liquid phase separation completely. Solvent was removed by freeze-drying for 3 days and the dried scaffolds were then kept in a desiccator until characterization or usage.
此方法是固液相分离法。把PLA溶在dioxane中,通过冷冻就可以固液相分离吗,什么原理啊?
冷冻后为什么会出现固液分离(solid-liquid phase separation)啊?

[ Last edited by wanss on 2010-11-29 at 19:15 ]
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dingsai

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小木虫: 金币+0.5, 给个红包,谢谢回帖
应该是低温下PLA和溶剂分别以各自的相存在,都是固体状态的,然后冻干溶剂挥发掉剩下多孔聚合物支架,其实不是分的那么细吧,固液在这就是指PLA和溶剂,仅供参考
12楼2013-11-03 17:15:06
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毁人不倦

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★ ★
americanyk(金币+2):tks 新虫 2010-11-27 16:15:31
wanss(金币+2): 2010-11-28 04:36:45
本人个人理解,首先溶剂带着溶质进入模具,然后降温冷却模具中的溶液,溶剂变为固体,形成模具设计的形状,然后抽真空除去溶剂,剩余溶质。不知道对不对?
2楼2010-11-27 15:39:40
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axiu3961

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wanss(金币+3): 2010-11-27 17:19:02
americanyk(金币+1):Thank you 2010-11-27 18:03:48
溶液配制后,先0°C下降温保持2个小时,去上层清夜再在低温冷冻,然后冻干去掉溶液。这样可能可以制作出多空支架。
3楼2010-11-27 16:59:51
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placopolymer

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shileinjut(金币+1):谢谢参与! 2010-11-28 00:03:29
冷冻,溶剂升华形成多孔
4楼2010-11-27 19:10:16
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