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| 当基因缺失或敲除时可抑制酸诱导的神经元损伤，但转染该基因后又可重建其敏感性.已有研究表明，在未受损的动物脑组织中，仅仅降低PH值至6.5或缺血并不会引起损伤，但当缺血合并酸中毒时，却可显著增强毒性作用，导致明显的脑损伤 |
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Carena
铁杆木虫 (知名作家)
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发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:38:33
发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:38:33
| Gene deletion and gene knock-out can restrain acid-induced neuronal injury. The transfection of the gene would, however, rebuild its sensitivity. Studies have shown that in animals' brain tissues ,which are free of damage, reduction of the PH value to 6.5 or the ischemia will not cause injury. But ischemia and acid, when combined together, would cause intoxication and greatly increase toxic effects , which will result in obvious brain damage. |
2楼2010-07-20 11:48:12
tianmin199
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发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:39:02
发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:39:02
| When the gene knockout or inhibits acid when induced neurons damage, but the genes and transfection rebuilding its sensitivity. Studies have shown that, in the intact animals in the brain, only lower PH value to 6.5 or ischemic damage, but will not cause ischemic merger acidosis, when can significantly increase but the toxic effects, resulting in significantly brain damage |
3楼2010-07-20 12:14:08
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发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:39:09
急速Q7(金币+6, 翻译EPI+1): 2010-07-30 07:48:52
发芽土豆(金币+1):Thx for your participation! 2010-07-20 22:39:09
急速Q7(金币+6, 翻译EPI+1): 2010-07-30 07:48:52
| When there is gene deletion or knockout, the acid-induced neuronal damage can be inhibited. The transfection of the gene would, however, rebuild its sensitivity. Studies have shown that in healthy animal brain tissues, neither decrease of the PH value to 6.5 nor ischemia alone causes any danage. But when ischemia and excessive acid are combined together, the toxicity would significantly increase, which results in obvious brain damage. |
4楼2010-07-20 22:23:19